Does Radical Lymphadenectomy Improve Survival in Esophageal and Gastroesophageal Junction Cancer?

Authors

  • Mahesh Mani Adhikari Thoracic Unit, Dept of Surgical Oncology B P Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Binay Thakur Thoracic Unit, Dept of Surgical Oncology B P Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Zhenqing Shun
  • Sagar Khatiwada Thoracic Unit, Dept of Surgical Oncology B P Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Sachee Bhattarai
  • Manoj Tiwari Thoracic Unit, Dept of Surgical Oncology B P Koirala Memorial Cancer Hospital, Bharatpur, Nepal

DOI:

https://doi.org/10.3126/njc.v8i1.68242

Keywords:

Esophageal Neoplasms, Esophagogastric Junction,, Lymph Node Excision

Abstract

Background: Esophageal carcinoma is one of the deadliest cancer in gastrointestinal system with 5-years survival of only 24%. Lymphnode metastasis has been associated with worse outcome. But the extent of lymphnode dissection has been a debate among surgeons worldwide. This study aimed to compare the overall survival of patients undergoing radical and non-radical lymphadenectomy in a tertiary referral cancer hospital in Nepal.

Methodology: This study included 634 patients of esophageal and gastroesophageal junction cancer who underwent surgical resection at our institution over a period of 2001- 2019. The patients were divided into 2 groups; radical lymphadenectomy (RLN) and non-radical lymphadenectomy (NRLN) groups. RLN group underwent two-field or three field lymphadenectomy for esophageal cancer and D2 or D2 + lower mediastinal lymphadenectomy for GEJ cancer. NRLN group underwent nodal sampling or D1 dissection.

Results: RLN was performed in 85.9%. NRLN was done in 14.1%. Surgery alone was performed in 47.1% and multimodality approach in 52.9% cases. Median survival for RLN and NRLN groups was 34 and 15 months, respectively (p < .001).

Conclusion: Improved median survival has been observed after radical lymphadenectomy for esophageal and GEJ cancer.

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Published

2024-07-30

How to Cite

Adhikari , M. M., Thakur, B., Shun, Z., Khatiwada, S., Bhattarai, S., & Tiwari, M. (2024). Does Radical Lymphadenectomy Improve Survival in Esophageal and Gastroesophageal Junction Cancer?. Nepalese Journal of Cancer, 8(1), 76–82. https://doi.org/10.3126/njc.v8i1.68242

Issue

Vol. 8 No. 1 (2024)

Section

Original Articles

License

Copyright (c) 2024 Nepalese Journal of Cancer

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