Long term survival and prognostic factors for Thymoma and Thymic carcinoma. Results from a tertiary care center

Authors

  • Binay Thakur Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Sun Zhenqing Thoracic Department of the Affiliated Hospital of Hebei University, China
  • Sagar Khatiwada Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Manoj Tiwari Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Shachee Bhattarai Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Shashank Shrestha Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Ashish Kharel Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Mahesh Mani Adhikari Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal
  • Asha Thapa Bharatpur Hospital Nursing College, Nepal

DOI:

https://doi.org/10.3126/njc.v8i1.68226

Keywords:

surgical resection, classification, Thymoma

Abstract

Background: Thymomas and thymic carcinoma are rare tumors though thymoma is the most common anterior mediastinal neoplasm. We aimed to determine the long-term survival after thymectomy and also to identify the poor prognostic factors of survival.

Methods: A retrospective analysis of tumors with the final diagnosis of thymoma or thymic carcinoma (n = 42) was done. Upfront surgery or a multimodality approach was used depending upon Masaoka-Koga stage. Statistical analysis was done using SPSS 26.0

Results: Median survival was 144, 97, 123, 45, 19 and 20 months in Masaoka-Koga stages 1, 2a, 2b, 3, 4a and 4b, respectively (p < 0.001). Median survival and five-year overall survival (OS) were 86 months and 60%, respectively. Median OS was 125, 25 and 24 months for R0, R1 and R2 resections, respectively (p < 0.001). Median OS was 123 months in no-tumor spillage group vs 24 months in tumor spillage group (p < 0.001).

Conclusion: Masaoka-Koga stage, resection status and intraoperative tumor spillage are the most important predictors of long-term survival.

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Published

2024-07-30

How to Cite

Thakur, B., Zhenqing, S., Khatiwada, S., Tiwari, M., Bhattarai, S., Shrestha, S., Kharel, A., Adhikari , M. M., & Thapa, A. (2024). Long term survival and prognostic factors for Thymoma and Thymic carcinoma. Results from a tertiary care center. Nepalese Journal of Cancer, 8(1), 1–8. https://doi.org/10.3126/njc.v8i1.68226

Issue

Vol. 8 No. 1 (2024)

Section

Original Articles

License

Copyright (c) 2024 Nepalese Journal of Cancer

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