Drug Dosage Adjustment of Chronic Kidney disease Patients at Nephrology Ward in Tertiary Care Hospital of Nepal

Authors

  • Sonu Pakhrin Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan, Nepal
  • Sumitra Shrestha Divine Healthcare Pvt. Ltd. Bharatpur-16, Chitwan, Nepal
  • Renu Karki School of Health and Allied Sciences, Pokhara University, Dhungapatan, Pokhara, Nepal
  • Nirmal Raj Marasine School of Health and Allied Sciences, Pokhara University, Dhungapatan, Pokhara, Nepal
  • Rajendra Lama Pokhara academy of Health sciences, Ramghat, Pokhara, Nepal
  • Mandip Pokharel Program Manager, Vennue Foundation, Nepal

Keywords:

appropriateness, chronic kidney disease, dose adjustment, drug dosage adjustment, Nepal, nephrology

Abstract

Background: Drug dosage adjustment is essential for chronic kidney disease patients (CKD) patients. If it is not done properly, this will lead to an increase in toxicity and a decrease in the effectiveness of therapy. The objective of the present study was to assess whether appropriate dosage adjustments were made in hospitalized CKD patients.

Methods: A descriptive cross-sectional study was carried out among 80 CKD patients with stage II to V admitted in the nephrology ward of Chitwan Medical College Teaching Hospital, Nepal between 1st August to 30th November 2018. All patients with renal clearance ≤90 ml/min/1.73 m2 were included for the analysis. Data concerning patient’s clinical, medications and dosages, laboratory findings were extracted from the medical record section.

Results: Total of 81 numbers of prescribed drugs was found in eighty hospitalized CKD patients. Twenty-seven were found requiring dose adjustment. Dose adjustment according to renal function was judged as necessary in 27 dose adjustment required drugs. Among these, 11 (40.7% of 27) drugs were considered appropriate in dosing, whereas 16 (59.3%) were found to be inappropriate. A total of 13 (81.3%) number of drugs were inappropriately adjusted in stage V patients.

Conclusion: Dosing errors were the most frequently observed challenge in the patient hospitalized with CKD. This study also intensified the need for strong monitoring of drug therapy which will bear in achieving the better therapeutic outcomes that improve the quality of life and decrease the various problems associated with dosing error.

DOI: https://doi.org/10.46405/ejms.v2i1.39

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Published

2020-04-17

How to Cite

Pakhrin, S., Shrestha, S., Karki, R., Marasine, N. R., Lama, R., & Pokharel, M. (2020). Drug Dosage Adjustment of Chronic Kidney disease Patients at Nephrology Ward in Tertiary Care Hospital of Nepal. Europasian Journal of Medical Sciences, 2(1), 41–50. Retrieved from https://nepjol.info./index.php/ejms/article/view/32772

Issue

Vol. 2 No. 1 (2020): Europasian Journal of Medical Sciences (EJMS) | 2020 (January - June) Issue 2

Section

Original Articles

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