Correlation of Biochemical Parameters among Diabetes patients attending Medicine OPD of Janaki Medical College Teaching Hospital

Abstract

Background and objectives: With increasing incidence of diabetes mellitus, the cardiovascular and renal complications associated with it are emerging as major concern. The morbidity and mortality associated with diabetes can be reduced by timely assessment of those risk factors. Our study evaluated lipid profile and renal function test in male and female diabetic patients as well as the correlation among those biochemical parameters.

Materials and methods: Blood sugar, lipid profile and renal function test were assessed in 249 confirmed type 2 diabetic patients attending medicine OPD of Janaki medical college teaching hospital (JMCTH), Ramdaiya-Bhawadi, Dhanusha, Nepal. Independent ‘t’ test was used to observe the gender difference in those parameters and Pierson correlation test was applied to look for correlation among different biochemical parameters.

Results: Significant difference was observed between male and female for FBS (p=0.05) and PPBS (p=0.003). Such significant difference between male and female was also noted for lipid profile parameters, TC (177.65+43.09 and 163.45+35.68 respectively, p=0.05), VLDL-C (33.47+16.51 and 28.83+14.00 respectively, p=0.018) and HDL-C (40.52+10.62 and 37.94+8.07 respectively, p=0.033). According to our study TC, TG, VLDL, LDL, HDL showed significant positive correlation with FBS and PPBS. Likewise, creatinine, urea, uric acid was also positively correlated with FBS and PPBS (p<0.05). Moreover, there was significantly high correlation of uric acid with TC, TG, VLDL, LDL (p<0.05). In addition, there was highly significant correlation between creatinine and sodium.

Conclusion: There was a significant difference for blood sugar and lipid profile among male and female diabetic patients. Correlation was seen between blood sugar and lipid profile; uric acid and lipid profile as well as creatinine and sodium.