Impact of Adipocytokines-Leptin and Adiponectin on Thyroid Stimulating Hormone among Hypothyroid Patients

Authors

  • P Eshita Department of Human Genetics, Andhra University, Visakhapatnam
  • B Dharani Priya Coordinator, BVK PG Courses, Visakhapatnam
  • G Sudhakar Department of Human Genetics, Andhra University, Visakhapatnam
  • G Paddaiah Department of Human Genetics, Andhra University, Visakhapatnam

DOI:

https://doi.org/10.3126/ajms.v5i2.8789

Keywords:

Adiponectin, Adipocytokines, Leptin, Thyroid Stimulating Hormone

Abstract

Background: Adipocytokines, secreted from the adipose tissues have profound effect on complex metabolic and endocrine functions. Among them, leptin and adiponectin are the most recognized molecules which influence body homeostasis and metabolism. Moreover, patients with thyroid disease usually exhibit disturbances of these metabolic activities. Thus adipocytokines and thyroid hormones may influence similar aspects of metabolic functions.

Objective: The main objective of current study was to evaluate the association and impact of leptin and adiponectin on thyroid stimulating hormone (TSH) among hypothyroid patients.

Materials and Methods: For the present study a total 350 individuals were enlisted, out of which 200 were hypothyroid patients and 150 age and sex matched healthy controls aged ≥ 12 years. The serum TSH, leptin and adiponectin concentration were measured by CLIA method and results were computed by statistical methods such as mean, standard deviation, standard error and correlation using MS-Excel 2007.

Result: Our data showed that hypothyroidism was more prevalent in the age group 30-50(62%) and an elevated TSH level was observed with advancing age among the patients as compared to controls. The inverse relation of leptin and adiponectin has been seen among the patients. When patients were compared with controls, they were with normal values which were in the range of standardized lab values leptin (3.7-13ng/dl) and adiponectin (5-10μg/ml).

Conclusion: In conclusion, our data interpreted variations in the level of leptin and adiponectin among the hypothyroid individuals with high TSH level. As abnormal levels of these adipocytokines indicates the risk for other metabolic diseases like cardiovascular disease, obesity etc.

DOI: http://dx.doi.org/10.3126/ajms.v5i2.8789

Asian Journal of Medical Science, Volume-5(2) 2014: 67-72

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Published

2013-12-11

How to Cite

Eshita, P., Priya, B. D., Sudhakar, G., & Paddaiah, G. (2013). Impact of Adipocytokines-Leptin and Adiponectin on Thyroid Stimulating Hormone among Hypothyroid Patients. Asian Journal of Medical Sciences, 5(2), 67–72. https://doi.org/10.3126/ajms.v5i2.8789

Issue

Vol. 5 No. 2 (2014)

Section

Original Articles

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