Vitamin E Supplementation and Markers of Oxidative Stress in Indian Acute Myocardial Infarction Patients

Authors

  • Ijen Bhattacharya Associate Professor, Department of Biochemistry, Meenakshi Medical College, Hospital & Research Institute, Enathur, Kanchipuram Tamilnadu
  • Rahul Saxena Assistant Professor, Department of Biochemistry, SMSR, Sharda Hospital, Sharda University, Greater Noida, U.P.
  • Raj Saxena Senior Research Fellow, Department of Clinical Research, Sikkim Manipal University, Manipal
  • Alok Milton Lal Associate Professor, Department of Biochemistry & Biochemical Engineering, Jacob School of Biotechnology & Bioengineering, SHIATS, Allahabad, U.P

DOI:

https://doi.org/10.3126/ajms.v5i2.8430

Keywords:

Oxidative stress, Glutathione peroxidase, uric acid, malionaldehyde

Abstract

Background: Reactive oxygen species have been identified as mediators of cell injury in a variety of cardiovascular complications including Myocardial Infarction (MI). It is conceivable that vitamin E supplementation can be used therapeutically due to its role in ameliorating antioxidant status and free radicals scavenging activity.

Aim: Therefore, the present study was undertaken to assess the markers of oxidative stress i.e. erythrocyte glutathione peroxidase (GSHPx) & malondialdehyde (MDA); plasma vitamin C, E, A and uric acid level in the blood samples of MI patients and to investigate the effect of in-vitro vitamin E supplementation in ameliorating the levels of these antioxidants in the blood sample of MI patients.

Material & Method: 60 MI subjects (age group 30-60 years) were taken for the study and 60 healthy individuals served as controls. In-vitro vitamin E supplementation in the blood samples of MI subjects were performed and above mentioned parameters were estimated by using standard methods. Data was compared statistically by using student t-test.

Result: Vitamin E supplementation brought about an improved antioxidants status with significantly raised vitamin C, E, A and GSHPx levels (p<0.05, p<0.001), and simultaneously depleted level of erythrocyte MDA (p<0.001) in blood samples of MI subjects. However, plasma uric acid levels remain unaltered (p<0.1).

Conclusion: These findings further support the preventive and cardio protective role of vitamin E supplementation in reducing oxidative stress levels in the blood samples of MI patients.

DOI: http://dx.doi.org/10.3126/ajms.v5i2.8430

Asian Journal of Medical Science, Volume-5(2) 2014: 46-53

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Published

2013-12-10

How to Cite

Bhattacharya, I., Saxena, R., Saxena, R., & Lal, A. M. (2013). Vitamin E Supplementation and Markers of Oxidative Stress in Indian Acute Myocardial Infarction Patients. Asian Journal of Medical Sciences, 5(2), 46–53. https://doi.org/10.3126/ajms.v5i2.8430

Issue

Vol. 5 No. 2 (2014)

Section

Original Articles

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