Susceptibility of knee osteoarthritis patients to develop cardiovascular disease - a clinical study

Authors

  • Rahul Sexana Assistant Professor, Department of Biochemistry, SMSR, Sharda Hospital Sharda University, Greater Noida, U.P.
  • Ijen Bhattacharya Associate Professor, Department of Biochemistry, Meenakshi Medical College, Hospital & Research Institute, Enathur, Kanchipuram Tamilnadu
  • Raj Sexana Senior Research Fellow, Department of Clinical Research, Sikkim Manipal University, Manipal

DOI:

https://doi.org/10.3126/ajms.v4i3.8169

Keywords:

Atherogenic index, inflammation, malondialdehyde, paraoxonase

Abstract

Background: Osteoarthritis (OA) is a process of progressive destruction of articular cartilage which makes the OA patients physically inactive and increases the probability to develop cardiovascular disease (CVD). Aim: The objectives of present study were to estimate atherogenic index, markers of oxidative stress and inflammation in knee OA patients of different Kellegren- Lawrence (KL) grade and clarify the probability of knee OA patients to develop future CVD risk with disease severity.

Methodology: Atherogenic index, plasma paraoxonase, C-reactive protein (CRP) and erythrocyte malondialdehyde (MDA) levels were estimated by using standard methods in 55 - 70 years aged 76 knee OA patients categorized into three groups (on the basis of KL grading scale) and 24 healthy subjects (control group). The obtained values were compared statistically by using student’s t-test.

Result: A significant reduction in the plasma paraoxonase and serum HDL cholesterol levels were observed in (p<0.05) Group II & III knee OA patients. Similarly, erythrocyte MDA, Total cholesterol/HDL ratio and plasma CRP levels were increased significantly in (p<0.05) Group II and III knee OA patients. However, these levels were found to be altered insignificantly (p<0.01) in Group I knee OA subjects as compared to controls.

 Conclusion: Thus, the probability of KL grade III and IV knee OA patients to develop future risk of CVD are more as characterized by elevated antherogenic index, systemic inflammation and oxidative stress and reflect the need of antioxodants supplementation along with drug of choice to reduce CVD risk in knee OA patients. 

DOI: http://dx.doi.org/10.3126/ajms.v4i3.8169  

Asian Journal of Medical Sciences 4(2013) 62-68

Downloads

Download data is not yet available.
Abstract
737
PDF
764

Downloads

Published

2013-06-20

How to Cite

Sexana, R., Bhattacharya, I., & Sexana, R. (2013). Susceptibility of knee osteoarthritis patients to develop cardiovascular disease - a clinical study. Asian Journal of Medical Sciences, 4(3), 62–68. https://doi.org/10.3126/ajms.v4i3.8169

Issue

Vol. 4 No. 3 (2013)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).