Efficacy of intraoperative subanaesthetic dose of ketamine on post-operative analgesia for patients undergoing single level lumbar discectomy under general anesthesia: A placebo control randomized clinical study

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DOI:

https://doi.org/10.3126/ajms.v14i11.56489

Keywords:

Ketamine; Lumbar discectomy; Postoperative analgesia; Sub-anesthetic dose

Abstract

Background: Sub-anesthetic ketamine is becoming increasingly popular for opioid sparing analgesic properties.

Aims and Objectives: This study was done to determine the efficacy of intraoperative infusion of sub-anesthetic dose of ketamine on post-operative analgesia in single level lumbar discectomy surgeries.

Materials and Methods: A prospective, randomized, and control study was carried on 60 patients of American Society of Anesthesiologists I and II aged between 18 and 65 years undergoing single level lumbar discectomy under general anesthesia. After induction of anesthesia, Group A received Ketamine 0.3 mg/kg intravenous (IV) bolus followed by infusion at 4 μg/kg/min and Group B received 0.9% saline bolus dose of similar volume and infusion was started at similar rate. Post-operative pain relief, opioid sparing effect, and side effects if any were recorded.

Results: There was significant difference (P<0.001) in post-operative Numeric Rating scores for initial 6 h in Group A patients compared to Group B and prolonged duration of analgesia (8.5 vs. 4.25 h) along with reduced postoperative tramadol consumption.

Conclusion: In lumbar spine discectomy, intraoperative ketamine infusion at sub-anesthetic doses produces more effective post-operative analgesia along with opioid sparing effect without any side effects.

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Published

2023-11-01

How to Cite

Sowmya Madihalli Janardhan Iyengar, Shankar Kantharaju, & Shubha Mysore Ramesh. (2023). Efficacy of intraoperative subanaesthetic dose of ketamine on post-operative analgesia for patients undergoing single level lumbar discectomy under general anesthesia: A placebo control randomized clinical study. Asian Journal of Medical Sciences, 14(11), 53–59. https://doi.org/10.3126/ajms.v14i11.56489

Issue

Vol. 14 No. 11 (2023)

Section

Original Articles

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Copyright (c) 2023 Asian Journal of Medical Sciences

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