A randomized, open-label, controlled, parallel-group comparative study of two varieties of Carica papaya leaves in dengue-induced thrombocytopenia

Authors

  • Shreeharsha ER Telemedicine Medical Officer, District Hospital, Tumakuru, Karnataka, India https://orcid.org/0009-0000-3217-7976
  • Vani Jayaraman Associate Professor, Department of Pharmacology, Sri Madhusudan Sai Institute of Medical Sciences and Research Centre, Muddenahalli, Karnataka, India
  • Kavitha S Associate Professor, Department of Pharmacology, Akash Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
  • Sai Sailesh Kumar Goothy Associate Professor, Department of Physiology, Sri Madhusudan Sai Institute of Medical Sciences and Research Centre, Muddenahalli, Karnataka, India https://orcid.org/0000-0002-5838-3994
  • Ravishankar SN Professor, Department of General Medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.3126/ajms.v14i9.53795

Keywords:

Carica papaya; Dengue fever; Thrombocytopenia; Platelets

Abstract

Background: Dengue-induced thrombocytopenia can be life-threatening. However, supportive and symptomatic treatment is the current management protocol. The leaf extract of papaya has shown promising results in improving the platelet count. There are many varieties of Carica papaya such as Washington, Honeydew, Coorg honeydew, Solo, Surya, Red lady, C0-1, CO-3, CO-5, C0-6.

Aims and Objectives: The aim is to evaluate the efficacy and safety of two varieties (“Red Lady” and “Solo”) of C. papaya fresh leaf extract in patients diagnosed with dengue-induced thrombocytopenia.

Materials and Methods: The study was conducted for 2 months, and 18 dengue-confirmed inpatients with thrombocytopenia (platelet count <1,50,000/μL) were enrolled. The study participants were grouped into the standard “Control” group, “Solo” group who received fresh papaya leaf extract “Solo” and “Red Lady” group who received fresh papaya leaf extract of “Red Lady.” About 30 mL of leaf extract was given thrice daily for 5 days.

Results: The mean change from the baseline value of platelets was found to be 59,168/µL for the control group and 57,000/µL for Red Lady, and 93,167/µL for the solo group. The study showed a positive trend with improvement in platelet count in “Solo” Variety group when compared to “Red Lady” group and the control group. The safety results showed that both the papaya leaf extracts have a favorable safety profile.

Conclusion: There was an improvement in platelet count in “Solo” variety group when compared to “Red Lady” and the control group. However, the results were not statistically significant. No adverse events were observed during the study.

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Published

2023-09-01

How to Cite

Shreeharsha ER, Vani Jayaraman, Kavitha S, Goothy, S. S. K., & Ravishankar SN. (2023). A randomized, open-label, controlled, parallel-group comparative study of two varieties of Carica papaya leaves in dengue-induced thrombocytopenia. Asian Journal of Medical Sciences, 14(9), 91–96. https://doi.org/10.3126/ajms.v14i9.53795

Issue

Vol. 14 No. 9 (2023)

Section

Original Articles

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Copyright (c) 2023 Asian Journal of Medical Sciences

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