Determination of serum KIM-1 in patients with chronic kidney injury

Authors

DOI:

https://doi.org/10.3126/ajms.v14i8.53228

Keywords:

Chronic kidney disease; KIM-1; Biomarker

Abstract

Background: Chronic kidney disease (CKD) affects more than 800 million people worldwide and is one of the leading non-communicable causes of death. Despite being a latent issue, once renal damage has started, the disease can rapidly progress to an advanced stage.

Aims and Objectives: Currently, the most commonly used markers for the diagnosis of renal disease are non-specific and insensitive. As a result, the goal of the current study is to investigate whether KIM-1 could be a precise and sensitive biomarker for identifying early kidney injury in CKD patients.

Materials and Methods: This case–control study recruited 155 participants from the Index Medical College Hospital v Research Centre, Indore, Madhya Pradesh, based on inclusion and exclusion criteria. 150 non-CKD subjects matched for age and sex were also taken from the hospital. The levels of KIM-1 were compared between CKD and non-CKD participants. Serum creatinine, urea, and creatinine clearance were also measured.

Results: The levels of KIM-1 were substantially higher in CKD patients than in non-CKD participants. In addition, a negative relationship between KIM-1 and creatinine clearance was observed with a P<0.05.

Conclusion: KIM-1 is a precise and sensitive kidney injury biomarker that can identify early kidney injury in CKD and contribute to the progression of interstitial fibrosis in kidney disease.

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Author Biography

Shreya Nigoskar, Professor and Head, Department of Biochemistry, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh, India

 

 

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Published

2023-08-01

How to Cite

Bansal, A., & Nigoskar, S. (2023). Determination of serum KIM-1 in patients with chronic kidney injury. Asian Journal of Medical Sciences, 14(8), 56–59. https://doi.org/10.3126/ajms.v14i8.53228

Issue

Vol. 14 No. 8 (2023)

Section

Original Articles

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Copyright (c) 2023 Asian Journal of Medical Sciences

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