Assessment of neutrophil and platelet-to-lymphocyte ratio as inflammatory markers in type 2 diabetes mellitus patients

Authors

DOI:

https://doi.org/10.3126/ajms.v14i4.51515

Keywords:

Neutrophil–lymphocyte ratio; Platelet–lymphocyte Ratio; Inflammation

Abstract

Background: Diabetes mellitus (DM), metabolic disease, and its prevalence are increasing in India. DM causes micro- and macrovascular complications. Inflammation is one of the contributing factor in the pathophysiology of DM.

Aims and Objectives: This study aimed to evaluate neutrophil and platelet-to-lymphocyte ratio (PLR) in T2DM patients.

Materials and Methods: This study was carried out in Biochemistry Department, Lt. B.R.K.M Government Medical College, Chhattisgarh, India. In this study, 150 type 2 DM patients were considered as cases and 150 normal subjects were considered as controls. Baseline data was collected from subjects. All subjects underwent physical and clinical examination. Fasting and post prandial venous blood samples were collected. FBS, PPBS, renal profile (urea, creatinine and uric acid) were estimated in serum sample. EDTA samples were used for complete blood count (CBC). Neutrophil-to-lymphocyte ratio (NLR) and PLR ratio were calculated from CBC values. HbA1c was estimated using whole blood sample. Blood pressure and BMI were recorded.

Results: In this study, mean age of 61.2±4.0 years, systolic blood pressure 136.2±14.4 mmHg, diastolic blood pressure 100.1±12.5 mmHg, BMI 28.1±2.6 (kg/m2), FBS 180.7±22.3 mg/dL, PPBS 289.3±33.2 mg/dL, HbA1c 8.1±0.7%, serum urea 39.1±8.3 mg/dL, creatinine 1.1±0.2 mg/dL, uric acid 7.1±2.0 mg/dL, lymphocytes 18.3±3.0%, NLR 8.1±3.1, and PLR 20.3±7.1 were significantly increased in cases than controls.

Conclusion: Elevated ratios of NLR and PLR may serve as markers of inflammation in T2DM. These are inexpensive and helpful to assess the inflammatory status in T2DM.

Downloads

Download data is not yet available.
Abstract
93
PDF
218

Downloads

Published

2023-04-01

How to Cite

Jyotindra Kumar Sahu, Rajeeb Kalita, Rajeev Gandham, & Ravikanth Medikonda. (2023). Assessment of neutrophil and platelet-to-lymphocyte ratio as inflammatory markers in type 2 diabetes mellitus patients. Asian Journal of Medical Sciences, 14(4), 50–53. https://doi.org/10.3126/ajms.v14i4.51515

Issue

Vol. 14 No. 4 (2023)

Section

Original Articles

License

Copyright (c) 2023 Asian Journal of Medical Sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).