Prevalence of multidrug resistant non-fermenters in a tertiary care centre

Authors

  • Veena Manjunath Associate Professor, Department of Microbiology, SS Institute of Medical Sciences and Research Centre, Davangere, Karnataka, India https://orcid.org/0000-0002-5307-1764
  • Shwetha Vadnal Revanappa Assistant Professor, Department of Microbiology, SS Institute of Medical Sciences and Research Centre, Davangere, Karnataka, India https://orcid.org/0000-0002-7530-1006
  • Asha Bullappa Associate Professor, Department of Preventive and Social Medicine, SS Institute of Medical Sciences and Research Centre, Davangere, Karnataka, India https://orcid.org/0000-0002-1567-5241
  • Jayasimha Vedalaveni Lakshminarayana Professor and Head, Department of Microbiology, SS Institute of Medical Sciences and Research Centre, Davangere, Karnataka, India https://orcid.org/0000-0001-9927-7082

DOI:

https://doi.org/10.3126/ajms.v13i10.46366

Keywords:

Pseudomonas aeruginosa; Acinetobacter baumannii.; Non-lactose fermenters; Multidrug resistant; Extensively drug resistant; Antimicrobial resistance; Nosocomial infections; Antimicrobial susceptibility testing

Abstract

Background: Infections due to multidrug resistant organisms especially Gram-negative non-fermenting bacteria such as Acinetobacter baumannii and Pseudomonas aeruginosa are increasing, ultimately leading to shortage of clinically effective antibiotics. Indiscriminate use of antibiotics is the key factor influencing the prevalence and distribution of drug resistance in any community or nosocomial setting.

Aims and Objectives: The objectives of the study are as follows: (1) To know the antibiotic susceptibility pattern of commonly isolated non-lactose fermenters. (2) To know the prevalence of multidrug resistant P. aeruginosa and A. baumannii.

Materials and Methods: Clinical samples from various departments were processed using standard isolation and identification procedures. Only non-lactose fermenting colonies were processed further and only those isolates that were identified as P. aeruginosa and A. baumannii. were considered and their antibiotic susceptibility testing by disk diffusion method was carried out. Results were tabulated and analyzed.

Results: Among 558 non-lactose fermenting Gram-negative bacilli isolates, P. aeruginosa (355) and A. baumannii. (203) were the most common isolates. Resistance to commonly used drugs such as aminoglycosides, cephalosporins and inhibitor combinations, and fluoroquinolones ranged from 40% to 65%. Carbapenem resistant isolates were around 24–25%. Multidrug resistant isolates and extensively drug resistant accounted for 17.4% and 9.1%, respectively.

Conclusion: Increasing multidrug resistance and extensive drug resistance resistance among non-fermenters are on the rise leaving a very small window of treatment options. This is an alarming situation that needs strict antibiotic policy and a robust antimicrobial resistance management plan.

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Published

2022-10-01

How to Cite

Manjunath, V., Vadnal Revanappa, S. ., Bullappa, A. ., & Vedalaveni Lakshminarayana, J. (2022). Prevalence of multidrug resistant non-fermenters in a tertiary care centre. Asian Journal of Medical Sciences, 13(10), 176–182. https://doi.org/10.3126/ajms.v13i10.46366

Issue

Vol. 13 No. 10 (2022)

Section

Original Articles

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