Effects of intravenous clonidine on hemodynamics and plasma cortisol level during laparoscopic urological surgeries in a tertiary care hospital

Authors

  • Ananya Saha Post Graduate Trainee, Department of Anaesthesia, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India https://orcid.org/0000-0002-1653-6884
  • Maitreyee Mukherjee Associate Professor, Department of Anaesthesia, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India https://orcid.org/0000-0001-5054-0927
  • Sovan Sikdar Clinical Tutor, Department of Anaesthesia, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India https://orcid.org/0000-0002-8142-8687
  • Sajib Chatterjee Associate Professor, Department of General Surgery, Raiganj Government Medical College and Hospital, Raiganj, West Bengal, India https://orcid.org/0000-0002-9340-1705
  • Arpita Laha Professor, Department of Anaesthesia, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India

DOI:

https://doi.org/10.3126/ajms.v13i9.44801

Keywords:

Clonidine; Cortisol; Laparoscopy; Pneumoperitoneum; Stress response; Urosurgery

Abstract

Background: Laparoscopic urologic surgeries causes rise in Blood pressure and heart rate. Maintenance of hemodynamics is an essential part of anaesthetic management.

Aims and Objectives: The aim of the study was to observe the effects of intravenous clonidine on heart rate (HR) and mean arterial pressure (MAP) and plasma cortisol level during laparoscopic surgeries.

Materials and Methods: In this ethical committee approved double-blind prospective interventional study, 50 adult patients of both sexes with ASA I and II were randomly allocated to two groups: Group C (3 mcg/kg Clonidine in 20 ml of Normal saline) and Group P (20 ml Normal saline). HR and MAP were recorded at different time intervals and blood samples were drawn before induction and after reversal from general anesthesia.

Results: In Group P there was a significant increase in variables during intubation, pneumoperitoneum and release of gas from the abdomen (P<0.001). In Group C mean plasma cortisol level increased from 19.36±1.49 (before induction) to 28.60±1.21 (after reversal) and in Group P from 19.33±1.30 to 32.28±1.66.

Conclusion: Clonidine may be a suitable and safe medication to attenuate hemodynamic stress response during laparoscopic surgeries.

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Published

2022-09-01

How to Cite

Saha, A., Mukherjee, M., Sikdar, S., Chatterjee, S., & Laha, A. . (2022). Effects of intravenous clonidine on hemodynamics and plasma cortisol level during laparoscopic urological surgeries in a tertiary care hospital. Asian Journal of Medical Sciences, 13(9), 47–56. https://doi.org/10.3126/ajms.v13i9.44801

Issue

Vol. 13 No. 9 (2022)

Section

Original Articles

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Copyright (c) 2022 Asian Journal of Medical Sciences

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