Association of glycosylated hemoglobin with urinary albuminuria for early detection and progression of renal damage in patients with type 2 diabetes mellitus

Authors

  • Moxda S Patel Assistant Professor, Department of Pathology, AMC MET Medical College, Ahmedabad, Gujarat, India https://orcid.org/0000-0002-3724-0185
  • Rugvi P Patel Senior Resident, Department of Pathology, AMC MET Medical College, Ahmedabad, Gujarat, India
  • Mananshi R Shah First Year Resident, Department of Pathology, Sumandeep Vidhyapith, Vadodara, Gujrat, India
  • Rajul R. Shah Assistant Professor, Department of Pathology, Smt.N.H.L.Municipal Medical College, Ahmedabad, Gujarat, India https://orcid.org/0000-0002-5619-8189

DOI:

https://doi.org/10.3126/ajms.v13i7.44353

Keywords:

Diabetes mellitus, Glycosylated hemoglobin, Microalbuminuria, Urinary albumin

Abstract

Background: Regular screening of levels of glycosylated hemoglobin and microalbuminuria (MA), diabetic nephropathy can be prevented.Recent studies found some of the sensitive and specific biomarker for early detection and progression of nephropathy in type 2 diabetes mellitus (T2DM) patients.

Aim and Objectives: This study was carried out to correlation of glycosylated hemoglobin with urinary albuminuria for early detection and progression of nephropathy in patients with T2DM.

Materials and Methods: This was a case–control study was conducted at tertiary care institute of India. A total 300 subjects included in the present study diagnosed with T2DM according to American diabetes association criteria and the cases are sub grouped based on albumin creatinine ration, the 100 patients T2DM with normoalbuminuria (NA) (ACR Ratio: <30 mg/dL) and 100 patients T2DM with MA (ACR Ratio: 30–299 mg/dL) along with that 100 healthy subjects were included in the study.FBS, PPBS, Urea, Creatinine, Uric acid, HbA1C, and Urinary Albumin was analyzed using laboratory standard methods.

Results: The plasma fasting blood sugar, post-prandial blood sugar, serum urea, creatinine, uric acid, Glycosylated hemoglobin, and urinary albumin levels were increased in two groups of T2DM Patients when compared to healthy controls. Significantly elevated levels of plasma fasting blood sugar, post-prandial blood sugar, serum urea, creatinine, uric acid, Glycosylated hemoglobin, and urinary albumin are observed in all the parameters elevated in between patients T2DM with MA when compared to patients T2DM NA.

Conclusion: Elevated levels of Glycated hemoglobin as well as urinary albumin were useful for detection and progression of different stages of nephropathy in patients with T2DM and also this study suggest that continuous monitoring of these investigations were useful for treatment of different stages of T2DM.

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Published

2022-07-01

How to Cite

Moxda S Patel, Rugvi P Patel, Mananshi R Shah, & Rajul R. Shah. (2022). Association of glycosylated hemoglobin with urinary albuminuria for early detection and progression of renal damage in patients with type 2 diabetes mellitus. Asian Journal of Medical Sciences, 13(7), 77–81. https://doi.org/10.3126/ajms.v13i7.44353

Issue

Vol. 13 No. 7 (2022)

Section

Original Articles

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Copyright (c) 2022 Asian Journal of Medical Sciences

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