An analytic cross-sectional study to explore the role of TNF-α level as a marker for diabetic polyneuropathy

Authors

  • Debarati Chanda Associate Professor, Department of Physiology, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0002-8990-2830
  • Aditi Aikat Professor, Department of Community Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India https://orcid.org/0000-0001-5448-1557
  • Saswati Ray Assistant Professor, Department of Physiology, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India
  • Sangita Sen Professor, Department of Physiology, IPGME and R, Kolkata, West Bengal, India
  • Debjani Chakraborti Professor, Department of Physiology, Jagannath Gupta Institute of Medical Sciences and Hospital, Kolkata, West Bengal, India

DOI:

https://doi.org/10.3126/ajms.v13i7.43808

Keywords:

Diabetic polyneuropathy, Painful neuropathy, Painless neuropathy, Tumour necrosis factor alpha, Type 2 diabetes mellitus

Abstract

Background: Diabetes has reached epidemic proportion in India. The most common complication of Type 2 diabetes mellitus (T2DM) is diabetic polyneuropathy (DPN). Various theories have been proposed to explain development of DPN, among which newer concepts are activation of inflammatory pathways.

Aims and Objectives: The aim of the study was to determine the relationship between tumor necrosis factor alpha (TNF-α) levels and painless and painful variants of DPN in T2DM patients.

Materials and Methods: The study was carried out on 57 subjects. The subjects were divided into four groups; Group 1 had 15 healthy controls without diabetes; Group 2 had 12 control group patients of T2DM without neuropathy; 20 patients of T2DM with painful neuropathy were included in Group 3 and 10 T2DM patients with painless neuropathy. TNF-α level was measured by drawing 5 ml blood from individual patients using Ray Bio Human TNF-α enzyme-linked immunoassay kit.

Results: Plasma TNF-α level increases from non-diabetic control (221.7±46.91 pg/ml) to diabetic control (743.6±87.27 pg/ml) and also further increased in painful neuropathy patients (1343±283.8 pg/ml). Interestingly, TNF-α was found to be significantly decreased (441.4±118.3 pg/ml) in patients with painless neuropathy.

Conclusion: TNF-α level increased in diabetic neuropathy but did not correlate with severity of neuropathy.

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Published

2022-07-01

How to Cite

Debarati Chanda, Aditi Aikat, Saswati Ray, Sangita Sen, & Debjani Chakraborti. (2022). An analytic cross-sectional study to explore the role of TNF-α level as a marker for diabetic polyneuropathy. Asian Journal of Medical Sciences, 13(7), 92–96. https://doi.org/10.3126/ajms.v13i7.43808

Issue

Vol. 13 No. 7 (2022)

Section

Original Articles

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