Role of LDH levels in differentiating anemias

Authors

  • Noorin Zaidi Associate Professor, Department of Pathology, Eras Lucknow Medical College and Hospital, Lucknow https://orcid.org/0000-0003-3182-4777
  • Rasha Zia Usmani Senior Resident, Department of Pathology, Government Medical College and Super Facility Hospital, Azamgarh
  • Kshama Tiwari Assistant Professor, Department of Pathology, Eras Lucknow Medical College and Hospital, Lucknow https://orcid.org/0000-0002-4369-8491
  • Sumaiya Irfan Assistant Professor, Department of Pathology, Eras Lucknow Medical College and Hospital, Lucknow https://orcid.org/0000-0001-7994-4132
  • Syed Riaz Mehdi Professor, Department of Pathology, Eras Lucknow Medical College and Hospital, Lucknow

DOI:

https://doi.org/10.3126/ajms.v12i9.37024

Keywords:

Lactate dehydrogenase, Megaloblastic anemia, Mixed deficiency anemia

Abstract

Background: There is a need to differentiate megaloblastic anemia from mixed deficiency anemia as both require different management protocols. With the acquisition of more information about them, tests such as serum vitamin estimation and Schilling test, were found to have their limitations. Hence there is a need to search newer diagnostic candidates to differentiate between megaloblastic anemia and mixed deficiency anemia.

Aims and Objective: The current study was undertaken to find usefulness of serum Lactate Dehydrogenase (LDH) in differentiating megaloblastic anemia from mixed deficiency anemia.

Materials and Methods: 100 patients were included in the study. Blood smears were stained and analysed. Complete blood counts were performed. Bone marrow examination was done, where needed. Biochemical tests were performed for estimation of vitamin B12, Folate and for LDH.

Results: Out of the 100 cases 51 were diagnosed as megaloblastic anemia and 49 were diagnosed as mixed deficiency anemia. The LDH levels were significantly higher in cases of megaloblastic anemia as compared to mixed deficiency anemia.

Conclusion: Serum LDH levels can be used in differentiating megaloblastic anemia from mixed deficiency anemia.

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Published

2021-09-01

How to Cite

Zaidi, N., Usmani, R. Z., Tiwari, K., Irfan, S., & Mehdi, S. R. (2021). Role of LDH levels in differentiating anemias. Asian Journal of Medical Sciences, 12(9), 79–83. https://doi.org/10.3126/ajms.v12i9.37024

Issue

Vol. 12 No. 9 (2021)

Section

Original Articles

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Copyright (c) 2021 Asian Journal of Medical Sciences

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