Upper intestine - New target for type-2 diabetes: A review

Authors

  • Srinivas Martha School of Medicine, Department of Pediatrics, Division of Weight Management & Wellness Center, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA
  • Javier de las Heras School of Medicine, Department of Pediatrics, Division of Weight Management & Wellness Center, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA
  • Srividya Ramreddy Department of Pharmaceutics, Sahasra Institute of Pharmaceutical Sciences, University College of Pharmaceutical Sciences, Kakatiya University, Warangal
  • Uday K Veldandi Department of Pharmacology & Clinical Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal
  • Narayana Pantam Department of General Medicine, MGM Hospital, Warangal

DOI:

https://doi.org/10.3126/ajms.v2i1.3403

Keywords:

Type-2 diabetes, Intestinal nutrients, Long chain fatty acids, intestine-brain-liver axis, metabolic surgery

Abstract

Type-2 diabetes is a chronic metabolic progressive disease, affects 200 million people worldwide will leads to increased death by more than 50% in the next 10 years. The ingested nutrients stimulate the release of gut peptides called incretins, which enhance the insulin secretion from pancreatic β cell, in addition to this, recently, another gut mediated mechanisms called intestine-brain-liver axis to regulate glucose homeostasis by a neural circuit, initiated in the intestine in response to nutrient sensing, that increases sensitivity to insulin levels. In this mini review, the underlying mechanisms of gut related glucose regulation and its impact on the management of type-2 diabetes mellitus.

Key Words: Type-2 diabetes; Intestinal nutrients; Long chain fatty acids; intestine-brain-liver axis; metabolic surgery

DOI: 10.3126/ajms.v2i1.3403

Asian Journal of Medical Sciences 2 (2011) 56-62

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Published

2011-05-15

How to Cite

Martha, S., de las Heras, J., Ramreddy, S., Veldandi, U. K., & Pantam, N. (2011). Upper intestine - New target for type-2 diabetes: A review. Asian Journal of Medical Sciences, 2(1), 56–62. https://doi.org/10.3126/ajms.v2i1.3403

Issue

Vol. 2 No. 1 (2011)

Section

Original Articles

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