Risk factors for persistent elevation of perioperative lactate levels in gastric cancer surgery

Authors

  • Selcuk Gulmez Medical Doctor, Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey http://orcid.org/0000-0001-9719-1904
  • Orhan Uzun Medical Doctor, Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey http://orcid.org/0000-0001-6550-0936
  • Aziz Serkan Senger Medical Doctor,Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey http://orcid.org/0000-0003-0981-0141
  • Zehra Zeynep Keklikkiran Medical Doctor,Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0001-6544-7418
  • Hilmi Bozkurt Medical Doctor, Department of General Surgery, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0003-0389-0523
  • Sinan Omeroglu Medical Doctor, Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey http://orcid.org/0000-0001-7992-5943
  • Emre Bozdag Medical Doctor, Department of General Surgery, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-2729-1667
  • Deniz Avan Medical Doctor, Department of Anesthesia, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-1650-7522
  • Erdal Polat Assistant Professor, Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-9463-9846
  • Mustafa Duman Professor of Surgery, Department of Gastrointestinal Surgery, University of Health Sciences, Kartal Kosuyolu Higher Specialty Training and Research Hospital, Istanbul, Turkey https://orcid.org/0000-0002-0276-0543

DOI:

https://doi.org/10.3126/ajms.v11i5.29743

Keywords:

Lactate, Hyperlactatemia, Surgery

Abstract

Background: The impact of high-risk surgery on tissue perfusion can be indirectly assessed by measuring lactate levels during surgery and intensive care unit (ICU) stay. While consistently high values are associated with poor prognosis, transient elevations do not mean poor clinical outcomes. Therefore, intraoperative and early postoperative blood lactate monitoring is essential for cancer patients.

Aims and Objective: This study aimed to determine the risk factors of persistently elevated lactate levels in the intraoperative and postoperative period in patients with elective gastric cancer surgery.

Materials and Methods: We retrospectively enrolled 293 patients who underwent curative resection for gastric cancer. Lactate values of all patients were examined during surgery and ICU-stay at 3rd, 6th, 12th, and 18th hours. All lactate values above 2 mmol/L were considered elevated. The patients were divided into two groups as those with perioperative persistently increased lactate levels and those without.

Results: Of the 293 patients, 60 (20.5%) had higher lactate levels in the perioperative period. According to multivariate logistic regression analysis, the operative time had the highest significance rate (p = 0.020) out of two significant variables, followed by the BMI ≥ 30 kg/m2 (p = 0.048). Besides, patients with perioperative hyperlactatemia had prolonged hospital stays (p = 0.034).

Conclusions: Operative time and obesity (BMI ≥ 30 kg/m2) were independent risk factors for persistent lactate elevation in the perioperative period. Also, perioperative hyperlactatemia extended the length of hospital stay.

Downloads

Download data is not yet available.
Abstract
373
PDF
382
Cover 11(5)

Downloads

Published

2020-09-01

How to Cite

Gulmez, S., Uzun, O., Senger, A. S., Keklikkiran, Z. Z., Bozkurt, H., Omeroglu, S., Bozdag, E., Avan, D., Polat, E., & Duman, M. (2020). Risk factors for persistent elevation of perioperative lactate levels in gastric cancer surgery. Asian Journal of Medical Sciences, 11(5), 24–28. https://doi.org/10.3126/ajms.v11i5.29743

Issue

Vol. 11 No. 5 (2020)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).