Blood levels of Polycyclic Aromatic Hydrocarbons in Women with Benign and Malignant Breast Lesions: A case-control study

Authors

  • Vipul K Singh Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow
  • M Anand Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow
  • D Rawtani Institute of Research & Development, Gujarat Forensic Science University, Gandhinagar
  • Uday P Singh Department of Forensic Science, Dr. BRA University, Agra
  • DK Patel Analytical chemistry section, Industrial Toxicology Research Centre, Lucknow
  • PK Mehrotra Department of General Surgery, Sir Ganga Ram Hospital, New Delhi
  • N Mathur Epidemiology section, Industrial Toxicology Research Centre, Lucknow
  • MKJ Siddiqui Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow

DOI:

https://doi.org/10.3126/ajms.v1i2.2924

Keywords:

Polycyclic Aromatic Hydrocarbons, Breast cancer, Benign lesions, HPLC-FD

Abstract

Objective: As part of our program to investigate the possible role of environmental pollutants in the incidence of breast cancer in India, we conducted for the first time a hospital based case-control study where blood polycyclic aromatic hydrocarbons (PAHs) levels were determined in women suffering from benign and malignant breast lesions, and compared with those of disease free controls drawn from similar socioeconomic environment residing in and around New Delhi, India.
Material & Methods: Anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo (a) pyrene, benzo (k) fluoranthene and dibenzo (a,h) anthracene were determined by HPLC-FD.
Results: Level of total PAHs in control, benign and malignant groups (30 numbers in each) were 142.05 ± 50.84, 185.99 ± 61.97 and 200.74 ± 55.05 μg / L respectively. Mean levels of naphthalene, phenanthrene, pyrene and benzo (k) fluoranthene were higher in both malignant and benign groups than in control but the difference was not statistically significant. Of the total PAHs, 3–ringed compounds were found much higher (89%) in controls than in benign (52%) and malignant groups (54%). However, the percentage sum of 2, 4 and 5-ringed PAHs were much higher in malignant (46%) and benign (48%) groups when compared with those of controls (11%).
Conclusion: Results of the present study indicate that higher levels of PAHs (especially non-carcinogenic), though statistically non-significant, were present in cases with benign and malignant breast lesions than in those of controls.

Key Words: Polycyclic Aromatic Hydrocarbons; Breast cancer; Benign lesions; HPLC-FD  

DOI: 10.3126/ajms.v1i2.2924

Asian Journal of Medical Sciences 1 (2010) 80-86

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Author Biographies

Vipul K Singh, Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow

M Anand, Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow

D Rawtani, Institute of Research & Development, Gujarat Forensic Science University, Gandhinagar

Uday P Singh, Department of Forensic Science, Dr. BRA University, Agra

DK Patel, Analytical chemistry section, Industrial Toxicology Research Centre, Lucknow

PK Mehrotra, Department of General Surgery, Sir Ganga Ram Hospital, New Delhi

N Mathur, Epidemiology section, Industrial Toxicology Research Centre, Lucknow

MKJ Siddiqui, Analytical toxicology section, Industrial Toxicology Research Centre, Lucknow

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Published

2011-01-14

How to Cite

Singh, V. K., Anand, M., Rawtani, D., Singh, U. P., Patel, D., Mehrotra, P., Mathur, N., & Siddiqui, M. (2011). Blood levels of Polycyclic Aromatic Hydrocarbons in Women with Benign and Malignant Breast Lesions: A case-control study. Asian Journal of Medical Sciences, 1(2), 80–86. https://doi.org/10.3126/ajms.v1i2.2924

Issue

Vol. 1 No. 2 (2010)

Section

Original Articles

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