Role of tranexamic acid to reduce blood loss and transfusion of allogeneic blood in the field of surgery

Authors

  • Indra K. Shrestha Resident, Department of Anesthesiology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming, Dianmian Avenue 374, 650101, China https://orcid.org/0000-0003-2379-2496
  • Yong Yu Si Professor and Director, Department of Anesthesiology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming, Dianmian Avenue 374, 650101, China https://orcid.org/0000-0002-3058-4284
  • Jian Ping Tao Professor and Vice Director, Department of Anesthesiology, Second Affiliated Hospital of Kunming Medical University, Yunnan, Kunming, Dianmian Avenue 374, 650101, China https://orcid.org/0000-0001-5511-6834

DOI:

https://doi.org/10.3126/ajms.v11i2.26205

Keywords:

Tranexamic acid, Blood loss, Transfusion, Surgery

Abstract

Tranexamic acid is widely used as an antifibrinolytic drug to reduce blood loss intraoperative and postoperative time periods as well as to reduce transfusion of allogeneic blood. After releasing in the market, multidisciplinary surgeries have wide use of tranexamic acid due to its antifibrinolytic effect to reduce bleeding and transfusion of blood. In literature, there were mentioned a few adverse effects like thromboembolism, seizure, anaphylactic reaction, etc which are still unsolved questions to date. The aim of this review to minimize the blood loss from acute bleeding in different situations by updating the doses used in a different clinical scenario,since the release of tranexamic acid. It also gives an idea about appropriate doses to reduce blood loss, need for blood transfusion, minimize adverse effects and to understand the wide scope of application of TXA to date.

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Published

2020-02-29

How to Cite

Shrestha, I. K., Si, Y. Y., & Tao, J. P. (2020). Role of tranexamic acid to reduce blood loss and transfusion of allogeneic blood in the field of surgery. Asian Journal of Medical Sciences, 11(2), 89–95. https://doi.org/10.3126/ajms.v11i2.26205

Issue

Vol. 11 No. 2 (2020)

Section

Review Articles

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