Relationship between Anthropometric indices, serum Leptin and Respiratory function in Myanmar male adult subjects

Authors

DOI:

https://doi.org/10.3126/ajms.v10i4.23974

Keywords:

Respiratory Function, Serum Leptin, Obesity

Abstract

Background: The role of leptin in respiratory function has been studied in specific respiratory disease. A little is known about the association of serum leptin level and respiratory function parameter in healthy subjects.

Aims and Objectives: This study aimed to investigate the relationship between anthropometric indices, serum leptin and respiratory function in Myanmar male adult subjects

Material and Methods: A community- based cross-sectional comparative study was carried out in 101 apparently healthy male adult subjects of age 18-45 years. All participants were categorized by anthropometric indices into non- obese (body mass index: BMI < 25 Kg/m2 and obese subjects (BMI > 30 Kg/m2). Differences in respiratory function parameter and serum leptin level were compared across the group. Spirobank II spirometer was used to measure respiratory function (FEV1, FVC, FEV1/FVC, PEFR and FEF25-75%). Serum leptin level was investigated by enzyme-linked immunosorbent assay.

Results: The percentage of predicted value of all respiratory function parameters of obese group was significantly lower than that of non-obese group (p <0.05). All respiratory function parameters were significantly and negatively correlated with body mass index (BMI) and waist circumference (WC). Median and interquartile range of serum leptin level in the obese group was 5.8(3.5-9.1) ng/mL and it was significantly higher than that of non-obese group [1.9(1.1-3.1) ng/mL, p <0.001]. Serum leptin level was significantly and negatively correlated with respiratory function parameters (FVC, FEV1/FVC, PEF and FEF25-75%).

Conclusion: Respiratory function declined with increasing anthropometric indices might be due to increased serum leptin level considered as systemic inflammatory effect of body.

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Author Biographies

Thurein Zaw, University of Medicine, Magway, Magway Regional Division, The Republic of Union of Myanmar

Lecturer, Department of Physiology

Zarchi Theint-Theint Hlaing, University of Medicine, Magway, Magway Regional Division,The Republic of Union of Myanmar

M.B.B.S, M.Med.Sc, Ph.D (Physiology), Lecturer, Department of Physiology

Mya Thanda Sein, University of Medicine, Magway, Magway Regional Division, The Republic of Union of Myanmar

Professor and Head, Department of Physiology

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Published

2019-06-21

How to Cite

Zaw, T., Hlaing, Z. T.-T., & Sein, M. T. (2019). Relationship between Anthropometric indices, serum Leptin and Respiratory function in Myanmar male adult subjects. Asian Journal of Medical Sciences, 10(4), 9–13. https://doi.org/10.3126/ajms.v10i4.23974

Issue

Vol. 10 No. 4 (2019)

Section

Original Articles

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