The enzymopathy of G6PD deficiency in Jordan: a demographic and biochemical analysis

Authors

  • Ahmed Al-Imam CERVO Brain Research Center, University of Laval, Canada and Department of Anatomy and Cellular Biology, College of Medicine, University of Baghdad, Iraq https://orcid.org/0000-0003-1846-9424

DOI:

https://doi.org/10.3126/ajms.v10i1.21358

Keywords:

Glucosephosphate dehydrogenase deficiency, G6PD, ABO blood-group system, Middle east, Arabs

Abstract

Background: G6PD deficiency is an inherited X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain circumstances.

Materials and Methods: Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping.

Results: Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of a protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis.

Conclusion: This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.

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Author Biography

Ahmed Al-Imam, CERVO Brain Research Center, University of Laval, Canada and Department of Anatomy and Cellular Biology, College of Medicine, University of Baghdad, Iraq

  1. CERVO Brain Research Center, University of Laval, Canada
  2. Department of Anatomy and Cellular Biology, College of Medicine, University of Baghdad, Iraq.
  3. The Canadian Association for Neuroscience
  4. The Japanese Association of Anatomists

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Published

2018-12-11

How to Cite

Al-Imam, A. (2018). The enzymopathy of G6PD deficiency in Jordan: a demographic and biochemical analysis. Asian Journal of Medical Sciences, 10(1), 25–32. https://doi.org/10.3126/ajms.v10i1.21358

Issue

Vol. 10 No. 1 (2019)

Section

Original Articles

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