Study of pro-oxidant status in acute myocardial infarction

Authors

  • Tanushri Khatua Demonstrator, Department of Biochemistry, I.P.G.M.E & R, Kolkata, West Bengal, India http://orcid.org/0000-0003-1169-4282
  • Chandan Sarkar Professor and Head, Department of Biochemistry, R.G.Kar Medical College, Kolkata, West Bengal,India
  • Sujit Kumar Dey Associate Professor, Department of Biochemistry, R.G.Kar Medical College, Kolkata, West Bengal,India
  • Biswajit Majumder Associate Professor, Department of Cardiology, R.G.Kar Medical College, Kolkata, West Bengal,India

DOI:

https://doi.org/10.3126/ajms.v9i4.19710

Keywords:

AMI, Oxidative stress, Non-diabetic, Non-hypertensive, Non-smoker, TBARS, LDL, HDL

Abstract

Background: Apart from several well documented risk factors; oxidative stress may play an important role in the pathogenesis of myocardial infarction. Our study has been designed to investigate the pro-oxidant status in AMI patients who have no previous history of diabetes, hypertension and habit of smoking.

Aims and Objectives: To measure the level of serum thiobarbituric acid reactive substances(TBARS) to assess the extent of oxidative damage in recently diagnosed cases of AMI and to look for any correlation between this stress marker and some of the lipid profile markers.

Materials and Methods: A cross sectional study was conducted in a tertiary care hospital with 50 non-diabetic, non-hypertensive, non-smoker AMI patients of either sex as Cases and 50 age and sex matched healthy Controls. The biochemical parameters were measured by validated techniques.

Results: Level of serum TBARS (4.78 ± 1.06 nmol/ml) has significantly increased (p<0.001) in cases with respect to control group(2.19±0.41 nmol/ml); a positive correlation between serum TBARS and LDL; a negative correlation between serum TBARS and HDL in cases.

Conclusion: Our study indicates an increased oxidative stress in AMI patients even in absence of some high risk factors which are oxidative stress inducers by themselves. This evidence suggests that oxidative stress itself may play an important role in the pathogenesis of myocardial infarction. So, the oxidative stress marker may have the importance in early diagnosis of AMI. It also suggests the potential appropriateness of antioxidant therapy in the prevention of AMI.

Asian Journal of Medical Sciences Vol.9(4) 2018 31-34

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Published

2018-07-02

How to Cite

Khatua, T., Sarkar, C., Dey, S. K., & Majumder, B. (2018). Study of pro-oxidant status in acute myocardial infarction. Asian Journal of Medical Sciences, 9(4), 31–34. https://doi.org/10.3126/ajms.v9i4.19710

Issue

Vol. 9 No. 4 (2018)

Section

Original Articles

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