A study of vascular endothelial growth factor in the cord blood of pre-eclamptics and healthy pregnant women

Authors

DOI:

https://doi.org/10.3126/ajms.v8i1.15711

Keywords:

Vascular Endothelial Growth Factor, Pre-eclampsia, cord blood

Abstract

Background: Pre-eclampsia(PE) is  the  most  frequently encountered  medical  complication  during  pregnancy. In developing countries PE   is a principal cause of maternal mortality. A disturbance  in  the  angiogenic/antiangiogenic  factors  and  in  the  hypoxia/placental re-oxygenation  process,  seems  to  activate a maternal  endothelial  dysfunction.

Aims and Objective: To estimate Vascular Endothelial Growth Factor ( VEGF )  level  in the cord blood of healthy and Preeclamptic ( PEc ) pregnant women and to associate this with Preeclamptic pregnancy.

Material and Methods: A case-control study ofUmbilical cord serum VEGF levels from women with uncomplicated pregnancies (control group, n=60) and pregnancies complicated by Pre-eclampsia (n=40). VEGF in the cord serum was estimated by SANDWICH Enzyme Linked Immunosorbent Assay method by using ELISA Kit and then compared between the two groups.

Results: The mean VEGF concentrations in the women who had pre-eclampsia  (578.62±468.3)  were lower than in the control group( 625.75±533.1) , but the difference was not statistically significant ( p= 0.8548). 

Conclusion VEGF plays a key role in the instability between endothelial dysfunction and angiogenesis that occurs during Preeclampsia.  VEGF levels might be a useful tool for the early diagnosis of Pre-eclampsia.

Asian Journal of Medical Sciences Vol.8(1) 2017 21-25

Downloads

Download data is not yet available.
Abstract
836
PDF
794

Downloads

Published

2017-01-03

How to Cite

Rawat, A., Gangwar, A. K., Ghildiyal, A., Srivastava, N., Tiwari, S., & Singh, U. (2017). A study of vascular endothelial growth factor in the cord blood of pre-eclamptics and healthy pregnant women. Asian Journal of Medical Sciences, 8(1), 21–25. https://doi.org/10.3126/ajms.v8i1.15711

Issue

Vol. 8 No. 1 (2017)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).