A study of vascular endothelial growth factor in the cord blood of pre-eclamptics and healthy pregnant women

Authors

DOI:

https://doi.org/10.3126/ajms.v8i1.15711

Keywords:

Vascular Endothelial Growth Factor, Pre-eclampsia, cord blood

Abstract

Background: Pre-eclampsia(PE) is  the  most  frequently encountered  medical  complication  during  pregnancy. In developing countries PE   is a principal cause of maternal mortality. A disturbance  in  the  angiogenic/antiangiogenic  factors  and  in  the  hypoxia/placental re-oxygenation  process,  seems  to  activate a maternal  endothelial  dysfunction.

Aims and Objective: To estimate Vascular Endothelial Growth Factor ( VEGF )  level  in the cord blood of healthy and Preeclamptic ( PEc ) pregnant women and to associate this with Preeclamptic pregnancy.

Material and Methods: A case-control study ofUmbilical cord serum VEGF levels from women with uncomplicated pregnancies (control group, n=60) and pregnancies complicated by Pre-eclampsia (n=40). VEGF in the cord serum was estimated by SANDWICH Enzyme Linked Immunosorbent Assay method by using ELISA Kit and then compared between the two groups.

Results: The mean VEGF concentrations in the women who had pre-eclampsia  (578.62±468.3)  were lower than in the control group( 625.75±533.1) , but the difference was not statistically significant ( p= 0.8548). 

Conclusion VEGF plays a key role in the instability between endothelial dysfunction and angiogenesis that occurs during Preeclampsia.  VEGF levels might be a useful tool for the early diagnosis of Pre-eclampsia.

Asian Journal of Medical Sciences Vol.8(1) 2017 21-25

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Published

2017-01-03

How to Cite

Rawat, A., Gangwar, A. K., Ghildiyal, A., Srivastava, N., Tiwari, S., & Singh, U. (2017). A study of vascular endothelial growth factor in the cord blood of pre-eclamptics and healthy pregnant women. Asian Journal of Medical Sciences, 8(1), 21–25. https://doi.org/10.3126/ajms.v8i1.15711

Issue

Vol. 8 No. 1 (2017)

Section

Original Articles

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