24 Hours Urinary Hydroxyproline - A Noninvasive, Cost-Effective and Early Biochemical Marker Which May be Used to Screen the Osteoporotic Lesion in Postmenopausal Women

Authors

  • Mousumi Das Senior Resident, Department of Biochemistry NRS Medical College, Kolkata
  • Utpal Kumar Biswas Professor and Head, Department of Biochemistry NRS Medical College, Kolkata
  • Arun Kumar Associate Professor, Department of Biochemistry Manipal College of Medical Sciences, Pokhara

DOI:

https://doi.org/10.3126/ajms.v6i4.11853

Keywords:

Postmenopausal women, Urinary hydroxyproline, Biochemical bone markers

Abstract

Introduction: Osteoporosis results due increased rate of bone turnover. It has multifactorial etiology and most common in women after menopause.

Objective: The current study was aimed to assess the rate of bone turnover towards detection of osteoporotic changes by measuring 24 hours urinary hydroxyproline which is an early as well as non- invasive biochemical bone marker.

Methods: Urinary hydroxyproline was measured in 40 postmenopausal women and compared with similar number of premenopausal women as controls.

Results: 24 hours urinary hydroxyproline levels were significantly higher (p<0.001) in postmenopausal women than premenopausal groups. This indicates a higher rate of bone turnover suggesting osteoporotic changes. 24 hour urinary hydroxyproline is also positively correlated (r= 0.934) with age.

Conclusion: The present study suggests that measurement of 24 hours urinary hydroxyproline which is a cost-effective and non- invasive technique, may be used for screening and early detection of osteoporotic changes in women of postmenopausal age group.

DOI: http://dx.doi.org/10.3126/ajms.v6i4.11853

Asian Journal of Medical Sciences Vol.6(4) 2015 21-24

 

 

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Author Biography

Mousumi Das, Senior Resident, Department of Biochemistry NRS Medical College, Kolkata

Department of Biochemistry, Senior Resident

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Published

2015-01-06

How to Cite

Das, M., Biswas, U. K., & Kumar, A. (2015). 24 Hours Urinary Hydroxyproline - A Noninvasive, Cost-Effective and Early Biochemical Marker Which May be Used to Screen the Osteoporotic Lesion in Postmenopausal Women. Asian Journal of Medical Sciences, 6(4), 21–24. https://doi.org/10.3126/ajms.v6i4.11853

Issue

Vol. 6 No. 4 (2015)

Section

Original Articles

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