Distribution pattern of ABO and Rh blood groups and their allelic frequencies among different ethnic groups in Malaysia

Authors

  • Md. Ruhul Amin Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan
  • Dwi Susanto Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan
  • Laila Naher Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan

DOI:

https://doi.org/10.3126/ajms.v6i4.11257

Keywords:

ABO Blood group, Race, Rh factor, Hardy-Weinberg Law, Malaysia

Abstract

Background: The experiment involved 4 different racial populations such as Malay (M), Chinese (C), Indian Tamil (I) and confounded population termed as Others (O) from 13 states and 1 federal territory in Malaysia.

Methods: A total of 1101 students in Universiti Malaysia Kelantan were surveyed for ABO blood type and Rh factor.

Results: Phenotypic frequencies were 0.24, 0.27, 0.09 and 0.40 in M; 0.26, 0.21, 0.06 and 0.38 in C; 0.27, 0.31, 0.09 and 0.33 in I and 0.11, 0.29, 0.09 and 0.51 in O for A, B, AB and O blood group, respectively. Rh+ve cases were found to be abundant and distributed as 0.92, 0.94, 0.89 and 0.79 among M, C, I and O race, respectively. Allele frequencies of IA, IB and i were estimated at 0.17, 0.20 and 0.63 in M; 0.19, 0.16 and 0.65 in C; 0.20, 0.23 and 0.57 in O, respectively. Insignificant χ2 (0.05, 2 = 5.991) interprets that ABO allele frequencies exist in Hardy-Weinberg equilibrium in all races. However, high magnitude of χ2 in M (5.463) signifies continued admixture in the M genetic population or the population is less stable than C and I. C and I are in more stabilized condition in this regard that might be because of closed breeding within them.

Conclusion: Results of this study might be useful to blood transfusion services in Malaysia apart from human population geneticists.

DOI: http://dx.doi.org/10.3126/ajms.v6i4.11257

Asian Journal of Medical Sciences Vol.6(4) 2015 25-29

 

Downloads

Download data is not yet available.
Abstract
1238
PDF
2411

Author Biography

Md. Ruhul Amin, Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Locked bag 100, 17600 Jeli, Kelantan

Faculty of Agro Based Industry

Associate Professor

Downloads

Published

2014-11-29

How to Cite

Amin, M. R., Susanto, D., & Naher, L. (2014). Distribution pattern of ABO and Rh blood groups and their allelic frequencies among different ethnic groups in Malaysia. Asian Journal of Medical Sciences, 6(4), 25–29. https://doi.org/10.3126/ajms.v6i4.11257

Issue

Vol. 6 No. 4 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons CC-BY-NC license that permits use, distribution and reprduction in any medium, provided the original work is properly cited and is not used for commercial purposes. The journal should be recognised as the original publisher of this work.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).