Differential response in lipid levels of type 2 diabetics and non-diabetic controls to falciparum malaria

Authors

  • Samuel Acquah Department of Medical Biochemistry, School of Medical Sciences, University of Cape Coast, Cape Coast
  • Benjamin Ackon Egham Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi
  • Salifu Bawa Diabetes Clinic, Cape Coast Teaching Hospital, Cape Coast
  • Johnson Nyarko Boampong Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast

DOI:

https://doi.org/10.3126/ajms.v6i1.10798

Keywords:

Falciparum malaria, type 2 diabetes, lipid profile, atherogenic indices

Abstract

Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana.

Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) were determined in 100 type 2 diabetics and 100 non-diabetic controls before and during falciparum malaria using the BT3000 autoanalyzer in a prospective case control study design. Atherogenic indices were computed.

Results: At baseline, diabetics recorded significantly (P < 0.05) lower level of LDL but higher levels of CHOL/LDL and TG/HDL ratios than controls. LDL correlated (P < 0.05) positively but negatively with CHOL and HDL respectively in the two study groups. During malaria, diabetics exhibited higher (P < 0.05) levels of CHOL and TG but lower level of HDL. Non-diabetic controls had malaria-induced elevated level in TG only. The positive correlation between LDL and CHOL was maintained in the two study groups. The TG levels of diabetics correlated (P < 0.05) positively with LDL and HDL during malaria. In the case of controls, a positive (P < 0.05) correlation was found between LDL and HDL during falciparum malaria.

Conclusion: Falciparum malaria modified the associations among the various

DOI: http://dx.doi.org/10.3126/ajms.v6i1.10798

Asian Journal of Medical Sciences Vol.6(1) 2015 71-76

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Published

2014-07-25

How to Cite

Acquah, S., Egham, B. A., Bawa, S., & Boampong, J. N. (2014). Differential response in lipid levels of type 2 diabetics and non-diabetic controls to falciparum malaria. Asian Journal of Medical Sciences, 6(1), 71–76. https://doi.org/10.3126/ajms.v6i1.10798

Issue

Vol. 6 No. 1 (2015)

Section

Original Articles

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