Quercetin as a Protease (á-Chymotrypsin) Inhibitor

Authors

  • GB Bajracharya Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur
  • DB Thapa Tri-Chandra Multiple Campus, Ghantaghar, Tribhuvan University

DOI:

https://doi.org/10.3126/njst.v14i2.10420

Keywords:

Allium cepa, á-chymotrypsin, DPPH assay, FRAP assay, quercetin 3, 3’, 4’, 7-tetramethyl ether

Abstract

Quercetin, isolated from the skin of red onion bulb, was methylated to afford quercetin 3,3’,4’,7-tetramethyl ether in 83.3% yield. Quercetin has displayed α-chymotrypsin inhibitory effect (IC50 = 88.9 ± 2.5 ìg/ml), DPPH free radical scavenging activity (IC50 = 14.87 ìg/ml) and ferric reducing power (EC1 = 112.94 ìM/l equivalent to 1 mM/l FeSO4.7H2O), whereas no enhancement of these biological activities was observed using its tetramethyl ether derivative.

DOI: http://dx.doi.org/10.3126/njst.v14i2.10420  

Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 91-96

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Published

2014-05-15

How to Cite

Bajracharya, G., & Thapa, D. (2014). Quercetin as a Protease (á-Chymotrypsin) Inhibitor. Nepal Journal of Science and Technology, 14(2), 91–96. https://doi.org/10.3126/njst.v14i2.10420

Issue

Vol. 14 No. 2 (2013)

Section

Articles

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