Efficacy of Statins in Dyslipidemia: A Non interventional comparative study in a tertiary care hospital, Ajman, UAE

Authors

  • LJ John Department of Pharmacology, Gulf Medical University, Ajman
  • EM Esheiba Department of Cardiology, GMC Hospital, Ajman
  • MAM Fathi Department of Cardiology, GMC Hospital, Ajman
  • AK Agarwal Department of Pharmacology, Gulf Medical University, Ajman
  • J Sreedharan Statistical Support Facility, CABRI, Gulf Medical University, Ajman
  • J Muttappallymyalil Department of Community Medicine, Gulf Medical University, Ajman
  • N Shantakumari Department of Physiology, Gulf Medical University, Ajman

DOI:

https://doi.org/10.3126/nje.v4i5.12023

Keywords:

Atorvastatin, Simvastatin, Rosuvastatin, Dyslipidemia

Abstract

Background
The reduction of serum total cholesterol and LDL-cholesterol levels varies with different statins. The objective of the present study was to compare the efficacy of Simvastatin, Atorvastatin and Rosuvastatin in the treatment of newly diagnosed dyslipidemia.

Material and Methods:
A prospective, non-interventional 12-week study was conducted after approval from the Ethics Committee. A total of 70 patients with newly diagnosed dyslipidemia receiving 20mg of Simvastatin, Atorvastatin or Rosuvastatin were included. The primary efficacy measure was reduction of lipid levels from the initial baseline values at the end of 12 weeks with the respective Statins. Data was analyzed using descriptive statistics, Paired -t test, and analysis of variance (ANOVA).

Results:
Of total 70 patients, 14 patients received Simvastatin; 40 patients received Atorvastatin and 16 patients received Rosuvastatin. Demographic and baseline clinical characteristics were similar between the three groups. Significant reduction in lipid levels (total cholesterol, and LDL) was seen within the three treatment groups (p<0.01). However, statistically significant difference in the reduction lipid levels was not observed between the three groups.

Conclusion:
We found no significant difference in the reduction of lipid levels between Simvastatin, Atorvastatin or Rosuvastatin patients with newly diagnosed dyslipidemia.

DOI: http://dx.doi.org/10.3126/nje.v4i5.12023

Nepal Journal of Epidemiology 2014; 4(5):428-32

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Author Biographies

EM Esheiba, Department of Cardiology, GMC Hospital, Ajman

Clinical Assistant Professor and Head of Department

MAM Fathi, Department of Cardiology, GMC Hospital, Ajman

Clinical Lecturer

AK Agarwal, Department of Pharmacology, Gulf Medical University, Ajman

Professor

J Sreedharan, Statistical Support Facility, CABRI, Gulf Medical University, Ajman

Professor

J Muttappallymyalil, Department of Community Medicine, Gulf Medical University, Ajman

Professor

N Shantakumari, Department of Physiology, Gulf Medical University, Ajman

Assistant Professor

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Published

2014-12-31

How to Cite

John, L., Esheiba, E., Fathi, M., Agarwal, A., Sreedharan, J., Muttappallymyalil, J., & Shantakumari, N. (2014). Efficacy of Statins in Dyslipidemia: A Non interventional comparative study in a tertiary care hospital, Ajman, UAE. Nepal Journal of Epidemiology, 4(5), 428–432. https://doi.org/10.3126/nje.v4i5.12023

Issue

Vol. 4 No. 5 (2014)

Section

Original Articles

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