Pyoderma Gangrenosum with Positive Antinuclear Antibody, in the Absence of Systemic Association

Authors

  • Smriti Shrestha Dhulikhel Hospital, Kathmandu University-Teaching Hospital, Dhulikhel, Kavre
  • Alisha Aryal Dhulikhel Hospital, Kathmandu University-Teaching Hospital, Dhulikhel, Kavre

DOI:

https://doi.org/10.3126/njdvl.v16i1.19418

Keywords:

Antibodies, connective tissue diseases, lupus erythematosus, vasculitis, leukocytoclastic

Abstract

Pyoderma gangrenosum is an uncommon neutrophilic dermatosis, seen on legs, and infrequently on hands and other anatomical sites. It is associated with systemic diseases in 50-70% of the cases. Antinuclear antibody (ANA) seropositivity has been reported in pyoderma gangrenosum associated with connective tissue disorders. However, there are very few case reports of pyoderma gangrenosum in patients of systemic lupus erythematosus, while we did not find any reports of ANA seropositivity in isolated pyoderma gangrenosum. Hence, we report this unique case of pyoderma gangrenosum with classical clinicohistopathology, positive ANA but no systemic association. As anticipated, our patient responded promptly to steroids.

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Author Biographies

Smriti Shrestha, Dhulikhel Hospital, Kathmandu University-Teaching Hospital, Dhulikhel, Kavre

Lecturer, Department of Dermatology

Alisha Aryal, Dhulikhel Hospital, Kathmandu University-Teaching Hospital, Dhulikhel, Kavre

Second Year Resident, Department of Dermatology

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Published

2018-03-29

How to Cite

Shrestha, S., & Aryal, A. (2018). Pyoderma Gangrenosum with Positive Antinuclear Antibody, in the Absence of Systemic Association. Nepal Journal of Dermatology, Venereology &Amp; Leprology, 16(1), 66–69. https://doi.org/10.3126/njdvl.v16i1.19418

Issue

Vol. 16 No. 1 (2018)

Section

Case Reports

License

Copyright on any research article is transferred in full to Nepal Journal of Dermatology, Venereology & Leprology upon publication.  The copyright transfer includes the right to reproduce and distribute the article in any form of reproduction (printing, electronic media or any other form).