Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy

Authors

  • Ishita Raka Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)
  • Madhur Kant Rastogi Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)
  • pratik gahalaut Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)
  • jaspreet kaur Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)
  • nitin mishra Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

DOI:

https://doi.org/10.3126/njdvl.v16i1.19402

Keywords:

Lipid peroxidation, Mycobacterium leprae, oxidants, reactive oxygen species, superoxide dismutase

Abstract

Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy.

Objective: To measure the enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy and compare them with healthy age & sex matched controls.

Materials and Methods: In this prospective study 30 untreated leprosy patients were included in the study and matched with 60 healthy controls. Biochemistry estimation was done with blood samples and MDA (lipid peroxidation), Nitric oxide (NO), (SOD) Superoxide dismutase (antioxidant enzyme), total oxidant status (TOS), total antioxidant status(TAS) and oxidative stress index (OSI) were estimated.

Results: Highly significant rise (p<0.0001) in serum MDA, NO, TOS and OSI was seen in leprosy patients when compared with controls with highly significant decline in SOD and TAS.

Conclusion: The study confirms the oxidative stress in leprosy and suggests antioxidant therapy may be used as an adjuvant in the treatment of leprosy along with MDT.

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Author Biographies

Ishita Raka, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

Senior Resident, Department of Dermatology

Madhur Kant Rastogi, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

Assistant Professor, Department of Dermatology

pratik gahalaut, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

Professor, Department of Dermatology

jaspreet kaur, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

Associate Professor, Department of Biochemistry

nitin mishra, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, (U.P)

Associate Professor, Department of Dermatology

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Published

2018-03-29

How to Cite

Raka, I., Rastogi, M. K., gahalaut, pratik, kaur, jaspreet, & mishra, nitin. (2018). Enzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy. Nepal Journal of Dermatology, Venereology &Amp; Leprology, 16(1), 35–40. https://doi.org/10.3126/njdvl.v16i1.19402

Issue

Vol. 16 No. 1 (2018)

Section

Original Articles

License

Copyright on any research article is transferred in full to Nepal Journal of Dermatology, Venereology & Leprology upon publication.  The copyright transfer includes the right to reproduce and distribute the article in any form of reproduction (printing, electronic media or any other form).