Recent advances in the use of Glycoprotein (GP) Ilb/Illa receptors inhibitors

Authors

  • Roshan Raut
  • Man Bahadur KC
  • Deewakar Sharma
  • Sujeeb Rajbhandari
  • Sajan G Baidhya

DOI:

https://doi.org/10.3126/njh.v4i1.26157

Keywords:

glycoprotein receptors inhibitors

Abstract

Glycoprotein IIb/IIIa receptors are the most common receptor subtypes on the platelet surface. During vessel injury, the sub-endothelial layer is exposed so that platelets adhere to sub-endothelial collagen via la/Ila receptor and to von Willebrand factor via glycoprotein Ib receptor. Adherent platelets are activated by ADP, 5-HT, TXA2 etc which result in the conformational change of platelets, thereby activating nearly 80,000 GP IIb/IIIa receptors on platelet surface. These activated receptors bind fibrinogen to fascilate the formation of a platelet plug.1,2

Downloads

Download data is not yet available.
Abstract
232
pdf
291

Downloads

Published

2006-11-30

How to Cite

Raut, R., KC, M. B., Sharma, D., Rajbhandari, S., & Baidhya, S. G. (2006). Recent advances in the use of Glycoprotein (GP) Ilb/Illa receptors inhibitors. Nepalese Heart Journal, 4(1), 112–124. https://doi.org/10.3126/njh.v4i1.26157

Issue

Vol. 4 No. 1 (2006)

Section

Review Articles

License

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.