Lack of Pharmacokinetic Interaction between Enalapril and Amlodipine with Phenytoin in Rhesus monkeys

Authors

  • SK Garg
  • DK Badyal
  • S Majumdar

DOI:

https://doi.org/10.3126/njh.v3i3.26143

Keywords:

enalapril, amlodipine, phenytoin

Abstract

A cross-over and multiple dose study was carried out to find out possible pharmacokinetic interactions between phenytoin (DPH 35 ma/kg; p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.

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Published

2004-11-30

How to Cite

Garg, S., Badyal, D., & Majumdar, S. (2004). Lack of Pharmacokinetic Interaction between Enalapril and Amlodipine with Phenytoin in Rhesus monkeys. Nepalese Heart Journal, 3(3), 75. https://doi.org/10.3126/njh.v3i3.26143

Issue

Vol. 3 No. 3 (2004)

Section

View Point

License

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