Comparative In Vitro Evaluation of Commercially Available Pantoprazole Tablets

Authors

  • Saffar Mansoor Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal
  • Rajeev Sharma Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal
  • Sophia Dhakal Department of Pharmacy, Kathmandu University, Dhulikhel, Nepal

DOI:

https://doi.org/10.3126/kuset.v3i1.64175

Abstract

Comparative study on in vitro evaluations (hardness, friability, weight variation, assay, disintegration, and dissolution tests) of marketed pantoprazole tablets (2 batches of each) from WHO GMP certified Nepalese companies (encoded with BP-02-A1, BP-02-A2), non-GMP certified Nepalese companies (encoded with BP-02-B1, BP-02-B2), and multinational companies (encoded with BP-02-C1, BP-02-C2) were done. The result of hardness, friability, weight variation, and assay and disintegration tests of all marketed products comply with pharmacopoeial limit. However, BP-02-A2 showed the fastest disintegration. Moreover, the comparison of percentage drug release of these companies on the basis of dissolution study demonstrated that BP-02-A2 (90 % drug release) complied best with standard RDRL protocol while BP-02-B2 (78% drug release) does not comply with above specification.

Downloads

Download data is not yet available.
Abstract
25
PDF
19

Downloads

Published

2007-01-31

How to Cite

Mansoor, S., Sharma, R., & Dhakal, S. (2007). Comparative In Vitro Evaluation of Commercially Available Pantoprazole Tablets. Kathmandu University Journal of Science, Engineering and Technology, 3(1). https://doi.org/10.3126/kuset.v3i1.64175

Issue

Vol. 3 No. 1 (2007)

Section

Short Communications

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.