Is Central Nervous System an Immune-Privileged Site?

Authors

  • R Shrestha Department of Pharmacology Dhulikhel Hospital-Kathmandu University Hospital Kathmandu University School of Medical Sciences Dhulikhel, Kavre
  • O Millington Centre of Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow
  • J Brewer Institute of Infection, Immunity and Inflammation College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow
  • T Bushell Centre for Neuroscience, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow

DOI:

https://doi.org/10.3126/kumj.v11i1.11055

Keywords:

Central nervous system, immune-privileged, blood-brain barrier, immune cells and lymphocytes

Abstract

The central nervous system (CNS) was once considered to be an immune-privileged area. However, increasing evidence shows that the central nervous system is not an immune-privileged but is an active surveillance site. There is a bi-directional communication between the central nervous system and immune system. Normally, immune cells migrate into the central nervous system microenvironment through choroid plexus and interact with the central nervous system resident cells through either through neuromediators or immunomediators. This finding has led to a significant interest in neuroimmunological interactions and investigation onto the role of the immune system in the pathology of various neurological disorders and examine whether it can be targeted to produce novel therapeutic strategies.

DOI: http://dx.doi.org/10.3126/kumj.v11i1.11055

Kathmandu University Medical Journal Vol.11(1) 2013: 102-107

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Author Biography

R Shrestha, Department of Pharmacology Dhulikhel Hospital-Kathmandu University Hospital Kathmandu University School of Medical Sciences Dhulikhel, Kavre

Lilly Research Centre, Eli Lilly and Company, Surrey, UK and Centre for Neuroscience, Strathclyde Institute of
Pharmacy and Biomedical Sciences, University of
Strathclyde, Glasgow, UK

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Published

2014-09-11

How to Cite

Shrestha, R., Millington, O., Brewer, J., & Bushell, T. (2014). Is Central Nervous System an Immune-Privileged Site?. Kathmandu University Medical Journal, 11(1), 102–107. https://doi.org/10.3126/kumj.v11i1.11055

Issue

Vol. 11 No. 1 (2013)

Section

Case Reports