Formulation and Evaluation of Fast Disintegrating Tablet of Salbutamol Sulphate

Abstract

INTRODUCTION

When put on the tongue, fast dissolving tablets immediately dissolve, often in a matter of seconds. They do not need any additional water to make them easier to swallow. Salbutamol sulphate fast disintegrating tablets have a higher bioavailability and dissolving rate.

MATERIAL AND METHODS

This experimental study was conducted in the Pharmaceutic laboratory of Department of Pharmacy at Universal College of Medical Sciences, Bhairahawa, Nepal from February 2022 to July 2022. A tablet was created utilizing the direct compression method employing mannitol as a diluent and various quantities of super disintegrants, including sodium starch glycolate, croscarmellose sodium, and PVPK-30 as a binder. Pre-compression and post-compression parameters for the formulation were evaluated.

RESULTS

When examined for hardness, thickness, weight variation, in vitro disintegration time, drug content, and in vitro drug release, tablets were determined to be adequate. Among all formulations, F6 showed that its disintegration time is least and in-vitro dissolution test depicts that F6 formulation shows the maximum drug release (99.99%) within 30 minutes.

CONCLUSION

This study brings the effectiveness in dosing of patients who have problem in swallowing of conventional dosage form. Among formulations, 15 mg of croscarmellose sodium was found to be the best.