An Update on Alcoholic Steatohepatitis

Authors

  • Bickram Pradhan Professor and In charge, Division of Gastroenterology and Hepatology, Department of Internal medicine, B P Koirala Institute of Health Sciences, Dharan
  • Lubina Arjyal Research Officer, B P Koirala Institute of Health Sciences, Dharan
  • Shatdal Chaudhary Associate Professor, Department of Internal Medicine, Universal College of Medical Sciences &Teaching Hospital, Bhairahawa

DOI:

https://doi.org/10.3126/jucms.v3i1.13263

Keywords:

Alcoholic steatohepatitis, ABIC score, Alcoholic hepatitis

Abstract

Alcoholic steato hepatitis (ASH) is an acute hepatic manifestation occurring from heavy alcohol ingestion. It is associated with liver failure, hepatorenal syndrome, severe sepsis and increased mortality. Patients with severe ASH have reported short-term mortality of up to 40%-50%. Although approximately 20% of alcoholics undergoing liver biopsy reveal histological features of alcoholic hepatites (AH) only a minority progress to severe alcoholic hepatitis (AH) with markedly elevated serum liver enzymes, jaundice and impaired liver function. Prognostic scores include the Maddrey's discriminant function, the model of end-stage liver disease, the Glasgow Alcoholic Hepatitis score, and the ABIC score. The response to corticosteroid therapy can be assessed using the Lille model. Severe ASH at risk of early death should be identified by one of the available prognostic scoring systems before considering specific therapies. Corticosteroids are the mainstay of treatment for severe ASH. When corticosteroids are contraindicated, Pentoxifylline may be alternatively used. This review article aims to discuss the clinical features, diagnosis, prognostic models, and treatment of ASH.

Journal of Universal College of Medical Sciences Vol. 3, No. 1, 2015: 54-59

Downloads

Download data is not yet available.
Abstract
763
PDF
810

Author Biography

Bickram Pradhan, Professor and In charge, Division of Gastroenterology and Hepatology, Department of Internal medicine, B P Koirala Institute of Health Sciences, Dharan

BP Koirala Institute of Health Sciences, Dharan

Downloads

Published

2015-09-03

How to Cite

Pradhan, B., Arjyal, L., & Chaudhary, S. (2015). An Update on Alcoholic Steatohepatitis. Journal of Universal College of Medical Sciences, 3(1), 54–59. https://doi.org/10.3126/jucms.v3i1.13263

Issue

Vol. 3 No. 1 (2015)

Section

Review Articles

License

Authors have to give the following undertakings along with their article:

  1. I/we declare that this article is original and has not been submitted to another journal for publication.
  2. I/we declare that I/we surrender all the rights to the editor of the journal and if published will be the property of the journal and we will not publish it anywhere else, in full or part, without the permission of the Chief Editor.
  3. Institutional ethical and research committee clearance certificate from the institution where work/research was done, is required to be submitted.
  4. Articles in the Journal are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)
  5. This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.