Biochemical Studies on Phenylhydrazine Induced Experimental Anemic Albino Rats

Authors

  • Nirjala Laxmi Madhikarmi Assistant Professor, Department of Biochemistry, M. B. Kedia Dental College, Birgunj
  • Kora Rudraiah Siddalinga Murthy Professor, Department of Biochemistry, Central College Campus, Bangalore University

DOI:

https://doi.org/10.3126/jucms.v3i1.13258

Keywords:

Albino rats, Anemia, Antioxidant, Lipid Peroxidation, Oxaidative Stress, Phenylhydrazine

Abstract

INTRODUCTION: The present study evaluated the modulatory effects of diphenylhydrazine induced experimental wistar albino rats and also to assess various biochemical parameters in whole blood and red blood cell lysate.

MATERIALAND METHODS: Twenty male albino rats weighing 180-200 gm were selected for the study and divided in two groups; ten phenylhydrazine dihydrochloride (PHZ) induced anemia and ten healthy control. Thiobarbituric acid reactive substances and lipid hydroperoxide were measured as lipid peroxidation parameter. The antioxidant vitamins A, C and E and enzymatic antioxidants; catalase, glutathione peroxidase and superoxide dismutase were also assessed.

RESULTS: Phenylhydrazine induced anemic rats showed a significant increase in the lipid peroxidation and decrease in the antioxidants as compared to healthy rats.

CONCLUSION: The study concludes that phenylhydrazine induced experimental anemic albino rats showed increased oxidative stress than compared with healthy albino rats.

Journal of Universal College of Medical Sciences Vol. 3, No. 1, 2015: 41-47


 

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Published

2015-09-03

How to Cite

Madhikarmi, N. L., & Murthy, K. R. S. (2015). Biochemical Studies on Phenylhydrazine Induced Experimental Anemic Albino Rats. Journal of Universal College of Medical Sciences, 3(1), 41–47. https://doi.org/10.3126/jucms.v3i1.13258

Issue

Vol. 3 No. 1 (2015)

Section

Original Articles

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