Serum levels of high sensitivity C-Reactive protein and its association with lipidemic status in Bangladeshi healthy adults

Abstract

Background: Metabolic diseases are affecting human health all over the world. These chronic disease states are associated with high sensitive CRP. The present study aims to measure hsCRP and lipid levels in a group of healthy adults to work out the normal hsCRP levels and explore its relationship to lipidemic and anthropometric variables.

Materials and Methods: A total of 149 adults, age 30-60 yrs, healthy subjects were recruited in this study. Vital statistics were taken along with measurement of blood glucose, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and hsCRP levels. Data were analyzed using statistical Package for Social Program (SPSS) for Windows version 10.

Results: Mean (±SD) hsCRP was 2.46±1.89 (mg/l) with a cut off value of 3mg/l. Of the total 149 subjects 102 (66.4%) and 47 (31.5%) subjects had hsCRP level below and above the cutoff respectively. Triglyceride was significantly higher (p=0.033) and HDL was lower in subjects with high hsCRP. Total cholesterol and LDL was almost similar in both groups. Binary logistic regression showed significant negative association between hsCRP and HDLc (p=0.029) and but the model excluding HDL-c showed significant positive association (p=0.03) with triglyceride.

Conclusion: About one-third of healthy Bangladeshi adults may have chronic subclinical inflammation and thus may have a risk of cardiovascular disorders. More than one-third healthy Bangladeshi adults have one or more type of dyslipidemia and the subclinical chronic inflammation in healthy Bangladeshi adults has a positive association with their serum triglyceride and negative association with their HDL-cholesterol levels.

DOI: http://dx.doi.org/10.3126/jpn.v4i8.11591

Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 644-648