Clinical and Biochemical Profile of Acute Liver Failure with Hepatic Encephalopathy in Children from Eastern Nepal

Authors

  • Gauri Shankar Shah Additional Professor, BP Koirala Institute of Health Sciences, Dharan
  • Manoj Kumar Singh Assistant Professor, Additional Professor, BP Koirala Institute of Health Sciences, Dharan
  • Dheeraj Shah Associate Professor, Additional Professor, BP Koirala Institute of Health Sciences, Dharan

DOI:

https://doi.org/10.3126/jnps.v31i2.4639

Keywords:

Acute liver failure, Hepatic encephalopathy, Mushroom poisoning

Abstract

Introduction: Hepatic encephalopathy is a potentially reversible neurophyschiatric abnormality in the setting of liver failure. Acute liver failure (ALF) is a potentially life-threatening disorder in children.

Objectives: The present study evaluated the clinical profile, outcome and factors influencing the outcome of children presenting with acute liver failure and hepatic encephalopathy presenting to a referral hospital of Eastern Nepal.

Methodology: Thirty children (17 males and 13 females) were admitted with this diagnosis during two year period.Prospective study.

Results: The most common cause of acute liver failure was mushroom poisoning seen in 30% of cases. Only 37% (11 out of 30) children survived, most of them in early stages (Stage I and II) of encephalopathy. Bleeding manifestations were significantly more common (P=0.002) in deaths as compared to survivors.

Conclusion: As liver failure is associated with high mortality rates especially in absence of facilities for liver transplantation, efforts should be directed in favor of implementing preventive measures such as vaccination and community education to prevent toxin ingestion.

Key Words: Acute liver failure; Hepatic encephalopathy; Mushroom poisoning

DOI: 10.3126/jnps.v31i2.4639

J Nep Paedtr Soc 2010;31(2):89-92

Downloads

Download data is not yet available.
Abstract
1200
PDF
629

Downloads

How to Cite

Shah, G. S., Singh, M. K., & Shah, D. (2011). Clinical and Biochemical Profile of Acute Liver Failure with Hepatic Encephalopathy in Children from Eastern Nepal. Journal of Nepal Paediatric Society, 31(2), 89–92. https://doi.org/10.3126/jnps.v31i2.4639

Issue

Vol. 31 No. 2 (2011)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).