Isoniazid Induced Psychosis: A Case Report

Authors

  • Taranjeet Kaur Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Kanwalpreet Kaur Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
  • Preeti Malhotra Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

DOI:

https://doi.org/10.3126/jnps.v39i3.28503

Keywords:

adverse effects, isoniazid, psychosis, tuberculosis

Abstract

Psychosis is a state of altered behaviour and mentation and it is not common in children. Isoniazid is a commonly used drug in the treatment and prophylaxis of tuberculosis. It may cause psychosis if overdosed but rarely with usual recommended doses. We report a case of drug induced psychosis secondary to isoniazid intake in a seven years old boy, who exhibited psychotic features about 10 days after the commencement of anti-TB combination drugs (Directly Observed Treatment Shortcourse) containing Isoniazid. This patient had no past medical or family history of mental illness. Drug induced psychosis was a possibility, and the responsible drug (isoniazid) was stopped. He improved following the withdrawal of isoniazid. Isoniazid psychosis is a major complication as iatrogenic psychiatric complications can greatly impact the patients’ quality of life, which if recognised early can be effectively treated.

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Author Biographies

Taranjeet Kaur, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Department of Paediatrics

Kanwalpreet Kaur, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Department of Paediatrics

Preeti Malhotra, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India

Department of Paediatrics

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Published

2019-12-31

How to Cite

Kaur, T., Kaur, K., & Malhotra, P. (2019). Isoniazid Induced Psychosis: A Case Report. Journal of Nepal Paediatric Society, 39(3), 189–192. https://doi.org/10.3126/jnps.v39i3.28503

Issue

Vol. 39 No. 3 (2019)

Section

Case Reports

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