Analysis of Predictors of Relapse in Children with Steroid Sensitive Nephrotic Syndrome

Authors

  • Mukesh Bhatta B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
  • Gauri Shankar Shah B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan
  • Om Prakash Mishra Banaras Hindu University, Varanasi 221005

DOI:

https://doi.org/10.3126/jnps.v37i1.17432

Keywords:

Nephrotic syndrome, Factors, Relapses

Abstract

Introduction: Children with idiopathic nephrotic syndrome (INS) are steroid responsive but have relapses in subsequent non-treatment period. The objective of the present study was to analyze the factors which could predict relapses in these children.

Material and Methods: Forty patients of INS aged 1-14 years of both gender were enrolled over one year period and followed for six months after treatment of initial episode of Nephrotic Syndrome.

Results: The median age of children was 4.5 years and male to female ratio 1.9:1. There were 24(60%) relapses and 16(40%) non-relapses. The relapses had significantly higher mean total leukocyte count, serum urea, potassium and cholesterol than non-relapses. It was also observed that the median age of onset in relapses was significantly lower than non-relapses (p<0.001). Also, the median time to response to steroid therapy was longer in relapses than non-relapses (p<0.001). Children who relapsed had infections at the time of relapse.

Conclusion: Thus, onset of disease in younger age group, late response to steroid therapy and presence of infections were found to be associated with relapses in these children.

Downloads

Download data is not yet available.
Abstract
1337
PDF
982

Author Biographies

Mukesh Bhatta, B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan

Resident, Department of Pediatrics and Adolescent
Medicine

Gauri Shankar Shah, B.P. Koirala Institute of Health Sciences (BPKIHS) Dharan

Professor, Department of Paediatrics and Adolescent
Medicine

Om Prakash Mishra, Banaras Hindu University, Varanasi 221005

Professor, Department of Paediatrics, Institute of Medical Sciences

Downloads

Additional Files

Published

2017-10-04

How to Cite

Bhatta, M., Shah, G. S., & Mishra, O. P. (2017). Analysis of Predictors of Relapse in Children with Steroid Sensitive Nephrotic Syndrome. Journal of Nepal Paediatric Society, 37(1), 1–4. https://doi.org/10.3126/jnps.v37i1.17432

Issue

Vol. 37 No. 1 (2017)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).