Emperical Oral Antibiotic Therapy for Children with Low Risk Febrile Neutropenia during Cancer Chemotherapy

Authors

  • PN Shrestha Department of Oncology Kanti Children’s Hospital, Kathmandu
  • K Sah Department of Oncology Kanti Children’s Hospital, Kathmandu
  • R Rana Department of Oncology Kanti Children’s Hospital, Kathmandu

DOI:

https://doi.org/10.3126/jnps.v29i1.1596

Keywords:

Febrile Neutropenia, Cancer Chemotherapy, ANC

Abstract

Introduction: In patient with fever and neutropenia during cancer chemotherapy who have a low risk of complications, oral antibiotic may be an acceptable alternative to intravenous antibiotics.

Methods: We conducted a prospective hospital based study to the patients who had fever and neutropenia during caner chemotherapy. Only low risk patients i.e. neutropenia of less than seven days, ANC >250/cmm, without any signs of shock were included in the study. All the patients were hospitalized and given oral antibiotics Ofloxacin and Amoxy-Clav and were closely observed until fever subsided for more than 48 hours and improved from neutropenia.

Results: A total of 54 cases were enrolled in the study. Out of 54 patients two patients were lost, 8 needed IV antibiotics for different reasons and 44 patients (81%) improved well with oral antibiotics only.

Conclusion: In hospitalized low risk patients who have fever and neutropenia, empirical therapy with oral ofloxacin and amoxy-clav may be a safe alternative to IV antibiotics.

Key words: Febrile Neutropenia, Cancer Chemotherapy, ANC.  

doi:10.3126/jnps.v29i1.1596

J. Nepal Paediatr. Soc. Vol.29(1) p.22-25   

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How to Cite

Shrestha, P., Sah, K., & Rana, R. (2009). Emperical Oral Antibiotic Therapy for Children with Low Risk Febrile Neutropenia during Cancer Chemotherapy. Journal of Nepal Paediatric Society, 29(1), 22–25. https://doi.org/10.3126/jnps.v29i1.1596

Issue

Vol. 29 No. 1 (2009)

Section

Original Articles

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