Synthesis and characterization of 2-pyridineformamide 3-pyrrolidinylthiosemicarbazone

Authors

  • B. Shakya Central Department of Chemistry, Tribhuvan University, Kathmandu
  • P. N. Yadav Central Department of Chemistry, Tribhuvan University, Kathmandu

DOI:

https://doi.org/10.3126/jncs.v29i0.9234

Keywords:

Pyrrolidine-1-carbothiohydrazide, Pyrrolidinylthiosemicarbazone, Reduction with sodium, Cyanopyridine

Abstract

Pyrrolidine-1-carbothiohydrazide was prepared by the transamination reaction of 4-methyl-4-phenyl-3-thiosemicarbazide with pyrrolidine in MeCN. 2-pyridineformamide 3-pyrrolidinyl-thiosemicarbazone (HAmPyrr) was synthesized by the reduction of cyanopyridine in the presence of pyrrolidine-1-carbothiohydrazide in MeOH with Na metal. The synthesized compound was characterized by elemental analysis, IR, 1H-NMR, 13C-NMR spectroscopy and ESI mass spectrometry. The prominent (M+1) peak (m/z) of HAmPyrr in the electron spray ionization mass spectrum was found at 250.09 which correspond to the molecular ion plus H. 

DOI: http://dx.doi.org/10.3126/jncs.v29i0.9234

Journal of Nepal Chemical Society

Vol. 29, 2012

Page: 28-33

Uploaded date : 12/3/2013

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Published

2013-12-03

How to Cite

Shakya, B., & Yadav, P. N. (2013). Synthesis and characterization of 2-pyridineformamide 3-pyrrolidinylthiosemicarbazone. Journal of Nepal Chemical Society, 29, 28–33. https://doi.org/10.3126/jncs.v29i0.9234

Issue

Vol. 29 (2012)

Section

Articles

License

© Journal of Nepal Chemical Society