Etiology of urinary tract infection and drug resistance cases of uropathogenes

Authors

  • CP Bhatt Associate Professor, Department of Microbiology, Kathmandu Medical College Teaching Hospital and Nobel College, Kathmandu
  • B Shrestha Microbiologist, Kathmandu Model Hospital, Kathmandu
  • S Khadka Nobel College, Kathmandu
  • S Swar Nobel College, Kathmandu
  • B Shah Nobel College, Kathmandu
  • K Pun Nobel College, Kathmandu

DOI:

https://doi.org/10.3126/jkmc.v1i2.8150

Keywords:

E. coli, MDR, Urinary tract infection

Abstract

Background: Multidrug resistant bacterial isolates have been frequently reported from different parts of the world as emerging treatment problem.

Objectives: The study was conducted to find out etiology of urinary tract infection and drug resistance trend among clinical pathogens in urinary tract.

Methods: Mid-stream urine samples from patients suspected of urinary tract infection were collected for routine culture and antibiotic susceptibility testing and were processed according to the standard laboratory methods.

Results: In this study 41.7% urine samples showed significant bacterial growth. Gram negative bacteria were the predominant organisms. Among them Escherichia coli was the predominant isolate (85.1%) whereas Enterococcus faecalis (40.6%), was the major Gram positive isolate. Among culture positive cases organisms were isolated in highest frequency (29.5%) in the age group 21 to 30 years. Urinary tract infections were found more common in females (61.1%) than in males (38.9%). Nitrofurantoin (82.2%) and Ofloxacin (57.8%) were found to be the most effective drugs against Gram negative organisms, whereas for Gram positive organisms, Nitrofurantoin (87.5%) and Gentamycin (78.1%) were found to be the most effective drugs. Escherichia coli was found sensitive to Nitrofurantoin (89.3%) followed by Ofl oxacin (63.3%). Enterococcus faecalis was most susceptible to Nitrofurantion (92.3%) followed by Cotrimoxazole (76.9%).

Conclusion: In this study, among the participants 41.7% had culture positive urinary tract infection. Drug resistance was found to be high in both Gram negative and Gram positive organisms. The high prevalence of drug resistance among urinary tract infection patients calls for the need of judicious measures for control of this infection and knowledge of patterns of resistance helps in deciding empirical therapy for urinary tract infection.

DOI: http://dx.doi.org/10.3126/jkmc.v1i2.8150

Journal of Kathmandu Medical College, Vol. 1, No. 2, Oct.-Dec., 2012: 114-120

Downloads

Download data is not yet available.
Abstract
849
PDF
2005

Downloads

Published

2013-05-26

How to Cite

Bhatt, C., Shrestha, B., Khadka, S., Swar, S., Shah, B., & Pun, K. (2013). Etiology of urinary tract infection and drug resistance cases of uropathogenes. Journal of Kathmandu Medical College, 1(2), 114–120. https://doi.org/10.3126/jkmc.v1i2.8150

Issue

Vol. 1 No. 2 (2012)

Section

Audit

License

Copyright © Journal of Kathmandu Medical College
The ideas and opinions expressed by authors or articles summarized, quoted, or published in full text in this journal represent only the opinions of the authors and do not necessarily reflect the official policy of Journal of Kathmandu Medical College or the institute with which the author(s) is/are affiliated, unless so specified.

Authors convey all copyright ownership, including any and all rights incidental thereto, exclusively to JKMC, in the event that such work is published by JKMC. JKMC shall own the work, including 1) copyright; 2) the right to grant permission to republish the article in whole or in part, with or without fee; 3) the right to produce preprints or reprints and translate into languages other than English for sale or free distribution; and 4) the right to republish the work in a collection of articles in any other mechanical or electronic format.