HEPATOPROTECTIVE PROPERTIES OF SELECTED PLANTS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE

Authors

  • Rajendra Gyawali Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Amita Shrestha Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Ashma Khanal Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Jyoti Sharma Pyakurel Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Nishchhal Joshi Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Pankaj Bajaj Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Pushparaj Chaudhary Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre
  • Roshni Thapa Department of Pharmacy, Kathmandu University, Dhulikhel, Kavre

DOI:

https://doi.org/10.3126/jist.v22i1.17766

Keywords:

Plants, Antioxidant, Hepatoprotective, Enzyme, Protein

Abstract

The hepatoprotective properties of the ethanolic extracts of Punica granatum peels, Crataeva religiosa leaves and Jasminum polyanthrum leaves were evaluated for the paracetamol induced liver toxicity in mice. Antioxidant, cytotoxicity and phytochemical screening were carried out to assure the therapeutic efficacy of these plants. Oral administration of plant extracts for 7 days in mice significantly reduced the impact of paracetamol toxicity on the serum markers of liver damage, aspartate transaminase (AST), alanine transaminase (ALT) and total protein. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities like ALT, AST and changed total protein. The phytochemical and antioxidant studies also supported that plant extract markedly reduced the toxicity due to presence of antioxidant phytochemicals. The result suggests that Jasminum polyanthrum is potent hepatoprotective agent against paracetamol induced hepatotoxicity in mice.

Journal of Institute of Science and Technology
Volume 22, Issue 1, July 2017, Page: 147-151

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Published

2017-07-18

How to Cite

Gyawali, R., Shrestha, A., Khanal, A., Pyakurel, J. S., Joshi, N., Bajaj, P., Chaudhary, P., & Thapa, R. (2017). HEPATOPROTECTIVE PROPERTIES OF SELECTED PLANTS AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE. Journal of Institute of Science and Technology, 22(1), 147–151. https://doi.org/10.3126/jist.v22i1.17766

Issue

Vol. 22 No. 1 (2017)

Section

Research Articles

License

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The copyright of the articles is held by the Institute of Science and Technology, T.U.