Antidiabetic Activity of <i>Laligurans</i> (<i>Rhododendron arboreum</i> Sm.) Flower

Authors

  • Megh Raj Bhandary Department of Food Technology and Quality Control, Kathmandu
  • Jun Kawabata Laboratory of Food Biochemistry, Division of Applied Bioscience

Keywords:

Laligurans, Rhododendron arboreum, Medicinal herb, a-Glucosidase inhibitor, Diabetes, Nepal

Abstract

Anti-diabetic activity was examined in Laligurans (Rhododendron arboreum Sm) flower and active compounds were isolated from it. Aqueous methanolic extract of the flower of Laligurans was found to show inhibitory activity on the rat intestinal ?-glucosidase. Both the water-soluble and ethyl acetate-soluble portions from the aqueous methanolic extract showed inhibitory activities on ?-glucosidase, demonstrating higher activity by the ethyl acetate-soluble portion. From the ethyl acetate-soluble portion, ?-glucosidase inhibitor quercetin-3-O-?-D-galactopyranoside (hyperin) was isolated through enzyme-assay guided separation. The isolated compound showed a dose dependent ?-glucosidase inhibitory activity with IC50 values of 1.66 mM and 0.76 mM for sucrase and maltase, respectively. This study revealed that Laligurans flower contains antidiabetic potential which property might be helpful to develop medicinal preparations, nutraceutical or functional food for diabetes and its complications.

Key words: Laligurans; Rhododendron arboreum; Medicinal herb; a-Glucosidase inhibitor; Diabetes; Nepal

Journal of Food Science and Technology Nepal Vol. 4, September, 2008, Page: 61-63

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Abstract
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Author Biographies

Megh Raj Bhandary, Department of Food Technology and Quality Control, Kathmandu

Research Officer; Department of Food Technology and Quality Control, Kathmandu, Nepal

Jun Kawabata, Laboratory of Food Biochemistry, Division of Applied Bioscience

Professor; Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan

 

Published

2009-06-30

How to Cite

Bhandary, M. R., & Kawabata, J. (2009). Antidiabetic Activity of <i>Laligurans</i> (<i>Rhododendron arboreum</i> Sm.) Flower. Journal of Food Science and Technology Nepal, 4, 61–63. Retrieved from https://nepjol.info./index.php/JFSTN/article/view/2001

Issue

Vol. 4 (2008)

Section

Articles

License

The author will be  the copyright holder of this open access journal - 'Journal of Food Science and Technology Nepal (JFSTN)'.