Prevalence and antimicrobial susceptibility pattern of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in CMS-teaching hospital: a preliminary report

Authors

  • RK Sanjana Assistant Professor, Dept. of Microbiology, College of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan District
  • Rajesh Shah Lecturer, Dept. of Microbiology, College of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan District
  • Navin Chaudhary Lecturer, Dept. of Microbiology, College of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan District
  • YI Singh Prof & Head, Dept. of Microbiology, College of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan District

DOI:

https://doi.org/10.3126/jcmsn.v6i1.3595

Keywords:

Nosocomial infection, methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant

Abstract

Aims: Nosocomial infection is a major problem in the world today. Methicillin-resistant Staphylococcus aureus (MRSA) strains, usually resistant to several antibiotics and also intrinsic resistance to ß-lactam antibiotics, shows a particular ability to spread in hospitals and now present in most of the countries. The present study was carried out to investigate the prevalence of MRSA and their rate of resistance to different antistaphylococcal antibiotics.

Materials and methods: Between April 2007 and December 2009, the clinical specimens submitted at the microbiology laboratory were processed and all Staphylococcus aureus (S. aureus) isolates were included in this study. All isolates were identified morphologically and biochemically by standard laboratory procedures and antibiotic susceptibility pattern including oxacillin was determined by modified Kirby Bauer disc diffusion method.

Results: Out of a total of 348 Staphylococcus aureus strains isolated from various clinical samples, 138 (39.6%) were found to be Methicillin-resistant. Among MRSA isolates, 86(62.3%) were from different inpatient departments, whereas, 52(37.7%) of the isolates were from outpatients. All MRSA were resistant to penicillin. More than 70% of the MRSA strains were resistant to cephalexin, ciprofloxacin and cloxacillin, while less than 10% of them were resistant to azithromycin, amikacin and tetracycline. Many MRSA strains were multidrug resistant. However, no strains were resistant to vancomycin.

Conclusion: This preliminary report showed a high prevalence of MRSA in our hospital. To reduce the prevalence of MRSA, regular surveillance of hospital acquired infection and isolation is the need of the hour.

Key words: Nosocomial infection; methicillin-resistant Staphylococcus aureus (MRSA); multidrug resistant.

DOI: 10.3126/jcmsn.v6i1.3595

Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 1, 1-6

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How to Cite

Sanjana, R., Shah, R., Chaudhary, N., & Singh, Y. (2010). Prevalence and antimicrobial susceptibility pattern of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) in CMS-teaching hospital: a preliminary report. Journal of College of Medical Sciences-Nepal, 6(1), 1–6. https://doi.org/10.3126/jcmsn.v6i1.3595

Issue

Vol. 6 No. 1 (2010)

Section

Original Articles

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