Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance

Authors

  • Xing Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Rajina Sahi B. P. Koirala Memorial Cancer Hospital
  • Yu-Yang Zhao Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Jun Wang Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Chun-Hui Li Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province

DOI:

https://doi.org/10.3126/jaim.v4i2.16897

Keywords:

Esophageal carcinoma, HPV 16-E6, Immunohistochemistry

Abstract

Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.

Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P<0.05), but not with the patient age, lymph node metastasis and tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.  

Downloads

Download data is not yet available.
Abstract
539
PDF
488

Downloads

Published

2017-03-05

How to Cite

Zhao, X., Sahi, R., Zhao, Y.-Y., Wang, J., & Li, C.-H. (2017). Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance. Journal of Advances in Internal Medicine, 4(2), 57–60. https://doi.org/10.3126/jaim.v4i2.16897

Issue

Vol. 4 No. 2 (2015)

Section

Original Articles

License

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator.