Association between level of HbA1c and lipid profile in T2DM patients attending diabetic OPD at BPKIHS

Abstract

Hyperglycemia, dyslipidemia and coronary artery disease relate well with each other in type 2 diabetes and it has been proposed that higher prevalence of cardiovascular disease in type 2 diabetes is due to chronic uncontrolled hyperglycemia. Our study aimed to find utility of Hba1c as indicator of dyslipidemia in patients with type 2 diabetes mellitus. We enrolled 168 T2DM patients in our study and collected venous blood samples in both plain and EDTA vials after a fast of minimum 8 hours. Biochemical analysis was done in fully automated analyzer cobas c311. HbA1c was found to have significant positive correlation with total cholesterol, LDL-C, and triglyceride and significant negative correlation with HDL-C and HDL/LDL ratio. The mean value of TC, LDL-C and TG was found to be lower in patients with good glycemic control than those with poor glycemic control. But, mean value of HDL and HDL/LDL ratios were found to be higher in patients with good glycemic control than those with poor glycemic control. These differences were significant at the level of p <0.05. Our study suggests additional use of HbA1c as indicator of dyslipidemia.

Health Renaissance 2015;13 (3): 16-23